Results 121 to 130 of about 3,009,889 (286)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Implementasi Alignment Point Pattern pada Sistem Pengenalan Sidik Jari Menggunakan Template Matching [PDF]

open access: yes, 2019
Fingerprints is one of biometric identification system. This is because fingerprints have unique and different pattern in every human, so identification using fingerprints can no longer be doubted.
Adiwijaya, A. (Adiwijaya)   +4 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Unsupervised Specific Emitter Identification Method Based on Directed Graph Connectivity

open access: yesShuju Caiji Yu Chuli
Specific emitter identification (SEI) refers to the technique of distinguishing emitters by utilizing unique and subtle features in received electromagnetic signals.
YANG Ning   +4 more
doaj   +1 more source

Dynamic Object Identification with SOM-based neural networks [PDF]

open access: yesComputer Science Journal of Moldova, 2014
In this article a number of neural networks based on self-organizing maps, that can be successfully used for dynamic object identification, is described. Unique SOM-based modular neural networks with vector quantized associative memory and recurrent self-
Aleksey Averkin   +3 more
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

IDENTIFIKASI IRIS MATA MENGGUNAKAN TAPIS GABOR WAVELET DAN JARINGAN SYARAF TIRUAN LEARNING VECTOR QUANTIZATION (LVQ)

open access: yesTeknik, 2012
Biometric represents the human identification method development using natural characteristic of humanbeing as its bases. Every iris has the detail and unique texture, even differ between right and left eye.Theeye iris identification process in this ...
Budi Setiyono, R. Rizal Isnanto
doaj  

Identification of Diptera Puparia in Forensic and Archeo-Funerary Contexts

open access: yesInsects
Diptera identification is fundamental in forensic entomology as well as in funerary archeoentomology, where the challenge is exacerbated by the presence of immature stages such as larvae and puparia. In these two developmental stages, specimens possess a
Stefano Vanin   +4 more
doaj   +1 more source

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