Results 31 to 40 of about 87,313 (246)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

UNIQUELY MORPHIC RINGS

Journal of Algebra and Its Applications, 2010
A ring R is called left morphic if, for each a ∈ R, R/Ra ≅ l(a) or equivalently there exists b ∈ R such that Ra = l(b) and l(a) = Rb, where l(a) and l(b) denote the left annihilators of a and b in R, respectively. Motivated by recent work on left morphic rings, we study the rings R satisfying the property that for each 0 ≠ a ∈ R there exists a unique ...
Kosan, M.Tamer, Lee, Tsiu-Kwen, Zhou, Yiqiang   +2 more
openaire   +5 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Some Inverse Source Problems of Determining a Space Dependent Source in Fractional-Dual-Phase-Lag Type Equations

Mathematics, 2020
The dual-phase-lag heat transfer models attract a lot of interest of researchers in the last few decades. These are used in problems arising from non-classical thermal models, which are based on a non-Fourier type law. We study uniqueness of solutions to
Frederick Maes, Marián Slodička
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Existence, uniqueness, localization and minimization property of positive solutions for non-local problems involving discontinuous Kirchhoff functions

Advances in Nonlinear Analysis
Let Ω⊂Rn\Omega \subset {{\bf{R}}}^{n} be a smooth bounded domain. In this article, we prove a result of which the following is a by-product: Let q∈]0,1[q\in ]0,1{[}, α∈L∞(Ω)\alpha \in {L}^{\infty }\left(\Omega ), with α>0\alpha \gt 0, and k∈Nk\in {\bf{N}}
Ricceri Biagio
doaj   +1 more source

On a Class of Nonlinear Elliptic Equations with General Growth in the Gradient

Mathematics
In this paper, we prove an existence and uniqueness result for a class of Dirichlet boundary value problems whose model is −Δpu=β|∇u|q+c|u|p−2u+fin Ω,u=0on ∂Ω, where Ω is an open bounded subset of RN, N≥2 ...
M. Francesca Betta, Anna Mercaldo, Roberta Volpicelli   +2 more
doaj   +1 more source