Results 91 to 100 of about 1,072,963 (337)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

An Optimization Strategy for Unit Commitment in High Wind Power Penetration Power Systems Considering Demand Response and Frequency Stability Constraints

Energies
To address the issue of accommodating large-scale wind power integration into the grid, a unit commitment model for power systems based on an improved binary particle swarm optimization algorithm is proposed, considering frequency constraints and demand ...
Minhui Qian, Jiachen Wang, Dejian Yang, Hongqiao Yin, Jiansheng Zhang   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Smart Grid Cost-Emission Unit Commitment via Co-Evolutionary Agents

Energies, 2016
In this paper, the uncertainty of wind, solar and load; smart charging and discharging of plug-in hybrid electric vehicles (PHEVs) to and from various energy sources; and the coordination of wind, solar power, PHEVs and cost-emission are considered in ...
Xiaohua Zhang, Jun Xie, Zhengwei Zhu, Jianfeng Zheng, Hao Qiang, Hailong Rong   +5 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Unit commitment with bidirectional ramping constraints of flexibility retrofit thermal power unit

International Journal of Electrical Power & Energy Systems
Flexibility retrofits of thermal power units have been widely implemented to improve power system balancing. These retrofits enable operation below the regular minimum output, known as deep peak regulation, to accommodate increasing renewable energy ...
Jingxiao Jiang, Yanran Zhu, Ying Wang, Xiaorui Guo, Jianhu Lv, Jianxiang Qin, Xingyun Yan, Kaifeng Zhang   +7 more
doaj   +1 more source

SELECCIÓN DE UNIDADES CON RESTRICCIÓN DE COMBUSTIBLE Y FLUJO ÓPTIMO DE POTENCIA PARA EL SISTEMA NACIONAL INTERCONECTADO

Revista Técnica Energía, 2008
El artículo establece una metodología para la selección de unidades y despacho óptimo de un sistema térmico, considerando las restricciones establecidas por la disponibilidad de combustibles. El problema modelado para la selección de unidades permite
Santiago Espinosa, Hugo Arcos
doaj   +1 more source

Transmission-Constrained Unit Commitment

, 2018
The unit commitment with transmission constraints in the alternating-current (AC) model is a challenging mixed-integer non-linear optimisation problem. We present an approach based on decomposition of a Mixed-Integer Semidefinite Programming (MISDP) problem into a mixed-integer quadratic (MIQP) master problem and a semidefinite programming (SDP) sub ...
Gambella, Claudio, Marecek, Jakub, Mevissen, Martin, Ortega, Jose Maria Fernandez, Djukic, Sara Pezic, Pezic, Mustafa   +5 more
openaire   +2 more sources

Contingency-Constrained Unit Commitment With Intervening Time for System Adjustments

, 2016
The N-1-1 contingency criterion considers the con- secutive loss of two components in a power system, with intervening time for system adjustments. In this paper, we consider the problem of optimizing generation unit commitment (UC) while ensuring N-1-1 ...
Chen, Richard Li-Yang, Fan, Neng, Guo, Zhaomiao, Watson, Jean-Paul   +3 more
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