Results 81 to 90 of about 13,095,517 (269)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Referat styremøte pensumlistekonsortiet 31/03 2020
, 2020 Referat fra styremøte i pensumlistekonsortiet 31/3 2020.Referat fra styremøte i pensumlistekonsortiet 31/3 ...
Unit
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Årsrapport pensumlistekonsortiet 2019
, 2020 Årsrapport pensumlistekonsortiet 2019.Årsrapport pensumlistekonsortiet ...
Unit
core
Referat styremøte pensumlistekonsortiet 13/12 2021
, 2021 Referat styremøte pensumlistekonsortiet 13/12 2021.Referat styremøte pensumlistekonsortiet 13/12 ...
Unit
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Møte i arbeidsgruppen for Oria 27-02-2020
, 2020 Referat fra møte i arbeidsgruppen for Oria 27-02-2020.Referat fra møte i arbeidsgruppen for Oria 27-02 ...
Unit
core
Referat styremøte pensumlistekonsortiet 01/06 2021
, 2021 Referat styremøte pensumlistekonsortiet 01/06 2021.Referat styremøte pensumlistekonsortiet 01/06 ...
Unit
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source