Results 111 to 120 of about 1,605,650 (307)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Type I and Type II Errors in the Unit Root Determination of a Fractional Brownian Motion [PDF]

Economists who deal with time-series data usually take the unit root test as the ‘prerequisite’ test for a Brownian motion. It is typical for any researchers to apply a battery of well-known unit root tests to their models to confirm stationarity in the ...
Power, Gabriel J., Turvey, Calum G., Wongsasutthikul, Paitoon   +2 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Is Current Account of Turkey Sustainable ? Evidence from Nonlinear Unit Root Tests

Romanian Economic Journal, 2015
In this paper, current account sustainability of Turkey is analyzed in a nonlinear framework. Various nonlinear unit root tests have been used to test for structural break, sign and size nonlinearity. We have tested structural break and size nonlinearity
Serkan Taştan , Kıvanç Halil Arıç
doaj  

Exploring the drivers of Indian agricultural exports: a dynamic panel data approach

Cogent Economics & Finance
This study delves into dynamics and determinants of agricultural exports from India. India’s agricultural export basket is heavily reliant on a limited range of commodities, including basmati rice, buffalo meat, spices, tea, coffee, and marine products ...
K. Nirmal Ravi Kumar, G. Mohan Naidu, Adinan Bahahudeen Shafiwu   +2 more
doaj   +1 more source

Testing for price convergence: how close are EU New Member's States to euro zone? [PDF]

The purpose of my paper is to empirically explore the validity of the relative version of purchasing power parity (PPP) for nine EU New Member States (NMS) using unit root and panel unit root frameworks.
Iuliana Matei
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Bootstrap Unit Root Tests in Panels with Cross-Sectional Dependency [PDF]

We apply bootstrap methodology to unit root tests for dependent panels with N cross-sectional units and T time series observations. More specifically, we let each panel be driven by a general linear process which may be different across cross-sectional ...
Yoosoon Chang
core  

Estimation for Unit Root Testing [PDF]

, 2013
We revisit estimation and computation of the Dickey Fuller (DF) and DF-type tests. Firstly, we show that the usual one step approach, based on the "DF autoregression", is likely to be subject to misspecification. Secondly, we clarify a neglected two step
Vougas, Dimitrios V.
core