Results 111 to 120 of about 109,072 (312)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

The Relationship Between Health Expenditures and Economic Growth in Turkey

open access: yesİstanbul Gelişim Üniversitesi Sosyal Bilimler Dergisi
Investments in human capital stock are the leading factors that increase economic growth. One of these investments is health expenditures. An increase in health expenditures in a country will contribute positively to the conscious society to benefit from
Murat Sağır, Sümeyya Kaplan
doaj   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

open access: yesFEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel   +9 more
wiley   +1 more source

Bayesian unit root testing

open access: yes, 2021
Η στασιμότητα μίας χρονοσειράς εξετάζεται από τους ελέγχους μοναδιαίας ρίζας. Η ύπαρξη μοναδιαίας ρίζας υποδηλώνει ότι η χρονοσειρά δεν είναι στάσιμη και γίνεται τυχαίος περίπατος. Η παρούσα διπλωματική εργασία ασχολείται με τον έλεγχο μοναδιαίας ρίζας σε αυτοπαλίνδρομα μοντέλα χρησιμοποιώντας μπεϋζιανές μεθόδους.
openaire   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

open access: yesFEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama   +7 more
wiley   +1 more source

Nonlinearity and stationarity of inflation rates: The results in the case of the Western Balkans [PDF]

open access: yesEkonomski Signali, 2019
In this article, we explored the nature of the dynamics and behavior of inflation in the case of the Western Balkans. The inflation rate, according to the test results, in most of the countries can be modeled as a stationary process.
Obradović Saša, Obradović Gordana
doaj  

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

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