Results 61 to 70 of about 4,186,989 (310)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Needlet-Whittle Estimates on the Unit Sphere [PDF]
, 2012 We study the asymptotic behaviour of needlets-based approximate maximum likelihood estimators for the spectral parameters of Gaussian and isotropic spherical random fields.
Claudio Durastanti +2 more
semanticscholar +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Compression on the digital unit sphere
Electronic Journal of Differential Equations, 2001 A method for compressing functions on the unit sphere is presented. This method is based on a Ramanujan set of rotations, and generates an equidistributed system of points.
Mohamed Allali
doaj
On the problem of retracting balls onto their boundary
Abstract and Applied Analysis, 2003 We provide some new estimates of the smallest possible Lipschitz constant for retractions of the unit ball B onto the unit sphere S in infinite-dimensional Banach spaces.
Kazimierz Goebel
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Rare diseases: a comprehensive literature review and future directions
Journal of Rare DiseasesRare diseases (RDs) affect a small percentage of the population but collectively impact millions worldwide. Their diagnosis and treatment remain challenging due to clinical heterogeneity, limited research, and high costs. Advances in genomics, artificial
Aryan Chaudhary, Vidyapati Kumar
doaj +1 more source
Estimation of Road Centerline Curvature From Raw GPS Data
The Baltic Journal of Road and Bridge Engineering, 2011 Development and wide use of route guidance systems lead to the need for suitable digital maps that can be used for some advanced applications. Sufficient accuracy of road geometry with emphasis on road centerline positions and curvature is crucial.
Peter Lipar +3 more
doaj +1 more source