Results 81 to 90 of about 4,848,832 (374)
FEBS Letters, EarlyView.Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen +13 more
wiley +1 more source
BMC Medical Ethics, 2020 Background The discovery of biomarkers of ageing has led to the development of predictors of impending natural death and has paved the way for personalised estimation of the risk of death in the general population.
Marie Gaille +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
Localized Bases for Kernel Spaces on the Unit Sphere [PDF]
SIAM Journal on Numerical Analysis, 2012 Approximation/interpolation from spaces of positive definite or conditionally positive definite kernels is an increasingly popular tool for the analysis and synthesis of scattered data and is central to many meshless methods.
E. Fuselier +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
Weighted energy problem on the unit sphere [PDF]
Analysis and Mathematical Physics, 2016 We consider the minimal energy problem on the unit sphere $\mathbb S^2$ in the Euclidean space $\mathbb R^3$ immersed in an external field $Q$, where the charges are assumed to interact via Newtonian potential $1/r$, $r$ being the Euclidean distance.
openaire +3 more sources
Optimal computation of brightness integrals parametrized on the unit sphere [PDF]
, 2012 We compare various approaches to find the most efficient method for the practical computation of the lightcurves (integrated brightnesses) of irregularly shaped bodies such as asteroids at arbitrary viewing and illumination geometries. For convex models,
M. Kaasalainen +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou +11 more
wiley +1 more source
On the problem of retracting balls onto their boundary
Abstract and Applied Analysis, 2003 We provide some new estimates of the smallest possible Lipschitz constant for retractions of the unit ball B onto the unit sphere S in infinite-dimensional Banach spaces.
Kazimierz Goebel
doaj +1 more source