Results 291 to 300 of about 6,119,383 (379)

Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia

open access: yesAdvanced Science, EarlyView.
Selective lesioning of SuM glutamatergic neurons promoted the induction of and delayed emergence from sevoflurane anesthesia and increased sevoflurane sensitivity. Optogenetic stimulation of SuM glutamatergic neurons or the SuM‐MS projection promoted behavioral arousal and cortical activation under steady‐state sevoflurane anesthesia and reduced the ...
Jiayan Li   +8 more
wiley   +1 more source

United Kingdom

open access: yes
Kate Hamblin   +2 more
openaire   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

open access: yesAdvanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei   +15 more
wiley   +1 more source

Large‐Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain

open access: yesAdvanced Science, EarlyView.
This study delineates both common and site‐specific proteins linked to various chronic pain conditions, elucidating their implications across molecular pathways and health status. These findings, particularly those proteins with genetic causal links to pain or predictive capabilities, have the potential to significantly benefit both research and ...
Ze‐Yu Li   +17 more
wiley   +1 more source

Gaseous Synergistic Self‐Assembly and Arraying to Develop Bio‐Organic Photocapacitors for Neural Photostimulation

open access: yesAdvanced Science, EarlyView.
By eliminating solvophobic driving forces and solvent interference, a physical vapor deposition based gaseous organization strategy is delivered, allowing Fmoc‐FF self‐assemble into spheres with tailored dimensions. Furthermore, arraying of the spheres can integrate their behaviors, endorsing the bio‐organic film the ability of programmable ...
Xinyuan Fan   +11 more
wiley   +1 more source

Abstract 17.30 PAIN MANAGEMENT FOR NON-SYNDROMIC CRANIOSYNOSTOSIS: ADEQUATE ANALGESIA IN A PEDIATRIC COHORT?

open access: yesPlastic and Reconstructive Surgery, Global Open, 2018
Alexandra Macmillan   +7 more
doaj   +1 more source

United Kingdom

open access: yes, 2019
Alvarez-Tinoco, Rocío   +2 more
openaire   +1 more source

Immunity Debt for Seasonal Influenza After the COVID‐19 Pandemic and as a Result of Nonpharmaceutical Interventions: An Ecological Analysis and Cohort Study

open access: yesAdvanced Science, EarlyView.
This study provides support for the immunity debt hypothesis, revealing a 131.72% increase in influenza rates during winter and a 161.23% rise in summer, 1 year following the global easing of COVID‐19 restrictions. This study offers empirical evidence of immunity debt on a global level, highlighting the importance of incorporating this concept into the
Li Chen   +6 more
wiley   +1 more source

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