Results 41 to 50 of about 7,167,653 (400)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

1918 Influenza Pandemic and Highly Conserved Viruses with Two Receptor-Binding Variants

open access: yesEmerging Infectious Diseases, 2003
The “Spanish influenza pandemic swept the globe in the autumn and winter of 1918–19, and resulted in the deaths of approximately 40 million people. Clinically, epidemiologically, and pathologically, the disease was remarkably uniform, which suggests that
Ann H. Reid   +7 more
doaj   +1 more source

Information Guide: United Kingdom [Polish] - Przewodnik informacyjny: Zjednoczone Królestwo [PDF]

open access: yes, 2016
Podręcznik zawiera źródła informacyjne dotyczące Zjednoczonego Królestwa Wielkiej Brytanii oraz Irlandii ...
EDC, Cardiff
core   +1 more source

Multi-utility service companies: a complex systems model of increasing resource efficiency [PDF]

open access: yes, 2015
Domestic households account for a significant portion of energy consumption and carbon emissions in the United Kingdom. Gains in energy and resource efficiency are undermined by the continuing rise in consumption.
Allen, Peter   +2 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Could a Tuberculosis Epidemic Occur in London as It Did in New York?

open access: yesEmerging Infectious Diseases, 2000
In early 1999, more than 160 senior physicians, public health officials, and nurses met to discuss London's tuberculosis (TB) control program. The program was examined against the public health response of New York City's Bureau of Tuberculosis Control ...
Andrew C. Hayward, Richard J. Coker
doaj   +1 more source

Human trafficking and the UK Modern Slavery Bill [PDF]

open access: yes, 2015
This article provides a commentary on growing awareness of human trafficking to and within the United Kingdom and government responses to ...
Craig, Gary
core   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

The Constitution of the United Kingdom [PDF]

open access: yesThe Cambridge Law Journal, 1999
Before the dawn of the millennium new legislative and executive authorities will have been established in Edinburgh, Cardiff and (subject to further political and other progress) in Belfast. This article analyses the nature of these constitutional initiatives, and examines their place in the unitary state which is the United Kingdom.
openaire   +4 more sources

Two cases of monkeypox imported to the United Kingdom, September 2018

open access: yesEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2018
In early September 2018, two cases of monkeypox were reported in the United Kingdom (UK), diagnosed on 7 September in Cornwall (South West England) and 11 September in Blackpool (North West England).
Aisling M Vaughan   +28 more
semanticscholar   +1 more source

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