Results 81 to 90 of about 6,119,383 (379)

From Shakespeare to Defoe: Malaria in England in the Little Ice Age

open access: yesEmerging Infectious Diseases, 2000
Present global temperatures are in a warming phase that began 200 to 300 years ago. Some climate models suggest that human activities may have exacerbated this phase by raising the atmospheric concentration of carbon dioxide and other greenhouse gases ...
Paul Reiter
doaj   +1 more source

Estimating the returns to United Kingdom publicly funded musculoskeletal disease research in terms of net value of improved health outcomes

open access: yesHealth Research Policy and Systems, 2018
BackgroundBuilding on an approach applied to cardiovascular and cancer research, we estimated the economic returns from United Kingdom public- and charitable-funded musculoskeletal disease (MSD) research that arise from the net value of the improved ...
M. Glover   +6 more
semanticscholar   +1 more source

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

open access: yesArthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner   +12 more
wiley   +1 more source

Brucellosis: an Overview

open access: yesEmerging Infectious Diseases, 1997
Brucellosis remains a major zoonosis worldwide. Although many countries have eradicated Brucella abortus from cattle, in some areas Brucella melitensis has emerged as a cause of infection in this species as well as in sheep and goats. Despite vaccination
Michael J. Corbel
doaj   +1 more source

Soil acidification and the importance of liming agricultural soils with particular reference to the United Kingdom

open access: yesSoil use and management, 2016
Soil acidification is caused by a number of factors including acidic precipitation and the deposition from the atmosphere of acidifying gases or particles, such as sulphur dioxide, ammonia and nitric acid.
K. Goulding
semanticscholar   +1 more source

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink

open access: yesArthritis Care &Research, EarlyView.
Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged ≥65 years. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Participants were aged ≥65 years registered with a UK general practice for at least 12 months between 1998 and 2018.
Jaspreet Kaur   +5 more
wiley   +1 more source

Long-term neuronal behavior caused by two synaptic modification mechanisms [PDF]

open access: yesarXiv, 2005
We report the first results of simulating the coupling of neuronal, astrocyte, and cerebrovascular activity. It is suggested that the dynamics of the system is different from systems that only include neurons. In the neuron-vascular coupling, distribution of synapse strengths affects neuronal behavior and thus balance of the blood flow; oscillations ...
arxiv  

An electrical load measurements dataset of United Kingdom households from a two-year longitudinal study

open access: yesScientific Data, 2017
Smart meter roll-outs provide easy access to granular meter measurements, enabling advanced energy services, ranging from demand response measures, tailored energy feedback and smart home/building automation.
David Murray   +2 more
semanticscholar   +1 more source

Priority Musculoskeletal Health Research Questions for People With Generalized Joint Hypermobility: An International Delphi Study

open access: yesArthritis Care &Research, EarlyView.
Objective This study aimed to identify the top 10 international research priorities for musculoskeletal health of people with generalized joint hypermobility. Methods A three‐round Delphi method using an online survey was implemented. Three participant stakeholder groups were eligible for inclusion: (1) people with lived experience of joint ...
Sara Habibian   +4 more
wiley   +1 more source

Effects of Pharmacologic and Nonpharmacologic Interventions for the Management of Sleep Problems in People With Fibromyalgia: Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

open access: yesArthritis Care &Research, EarlyView.
Objective Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain and fatigue. Almost everyone with fibromyalgia has sleep problems. We aimed to evaluate the effectiveness and safety of current interventions for the management of fibromyalgia‐related sleep problems.
Jemma Hudson   +11 more
wiley   +1 more source

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