Results 71 to 80 of about 269,228 (306)

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Bioenergy Cropping Reduces the Spatiotemporal Scaling of Soil Bacterial Biodiversity

Advanced Science, EarlyView.
Consistent with patterns observed in plant and animal communities, soil bacterial communities exhibit significant species–time–area and phylogenetic–time–area relationships independent of nested structure. Bioenergy cropping significantly reduces the spatiotemporal scaling rates, particularly in sandy loam soils.
Zhencheng Ye, Jialiang Kuang, Colin T. Bates, Arthur Escalas, Daliang Ning, Liyou Wu, Suo Liu, Sihang Deng, Jiesi Lei, Xiangwen Chen, Jennifer Pett‐Ridge, Malay Saha, Lauren Hale, Gangsheng Wang, Renmao Tian, Ying Fu, Yu Tang, Mary Firestone, Jizhong Zhou, Yunfeng Yang   +19 more
wiley   +1 more source

Midlife mortality in White non-Hispanic male veterans enrolled in Department of Veterans Affairs primary care, 2003–2014

Heliyon, 2020
Background: After years of decline in mortality rates in the United States, there have been increases in mortality rates in White non-Hispanic Americans ages 45–54, due to increases in deaths from suicide, poisoning, and alcoholic liver disease ...
Chuan-Fen Liu, Paul Hebert, Edwin S. Wong, Karin Nelson, Charles Maynard   +4 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Tridiet-enhanced weight gain in Sprague Dawley rats: a retrospective analysis

Frontiers in Nutrition
IntroductionObesity research, including our prior studies, commonly utilizes high-fat (HF) diets to induce weight gain in animal models. Here, we report on outcomes during ad libitum access to a triple (TRI) diet consisting of HF, high-glucose (HG), and ...
Amanda L. Rodriguez, Cameron Bradfield, Nicholas V. Scarpa, Bianca E. Barroso, Michael I. Fernandez, Sofia V. Cabanillas, Abigail Deleon-Pena, Elise Frias, Victor I. Agboli, Shoumi Sarkar, Shoumi Sarkar, Somnath Datta, Matthew A. Schiefer, Matthew A. Schiefer   +13 more
doaj   +1 more source

Millimeter‐Scale Dual‐Opposing RNA‐Gradient Hydrogel for Interfacial Gene Silencing

Advanced Science, EarlyView.
A branched microfluidic platform enables the fabrication of millimeter‐scale hydrogels with dual‐opposing RNA‐gradients for precise spatial control of cell gene expression. This device allows for the generation of multiple constructs at once, offering potential for future engineering of complex tissue interfaces with improved physiological relevance ...
Tyler Hoffman, Cong Truc Huynh, Marcus J. Goudie, Peyton J. Tebon, Hyojin Ko, Minh Khanh Nguyen, Kaelyn L. Gasvoda, Yang Song, Kirsten Fetah, Ali Khademhosseini, Song Li, Eben Alsberg   +11 more
wiley   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Food insecurity in veteran households: findings from nationally representative data [PDF]

, 2015
OBJECTIVE: The present study is the first to use nationally representative data to compare rates of food insecurity among households with veterans of the US Armed Forces and non-veteran households.
Byrne, Thomas H., DeVoe, Ellen, Larson, Mary Jo, Miller, Daniel P.   +3 more
core   +2 more sources

The Role of Social Food Infrastructure in Addressing SNAP Participation Gaps: Evidence From Linked Administrative and Ground‐Sourced Data

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We link American Community Survey and SNAP records for 185,000 units with ground‐sourced social food infrastructure data from FindFoodIL (Illinois Extension SNAP‐Ed) to examine SNAP participation determinants among eligible units. Bivariate probit models reveal, beyond SNAP offices, quantity of social infrastructure is associated with ...
Michael Lotspeich‐Yadao, Caitlin Kownacki, Jennifer McCaffrey, Craig Wesley Carpenter   +3 more
wiley   +1 more source

Supporting Our Region's Veterans: Assessing the Network of Services Available for Post 9/11 Veterans and Their Families in Northern Virginia [PDF]

, 2014
Just across the river from our nation's capital, NOVA is home to countless icons representing the history of warfare in the United States and the sacrifices that have been made for our freedoms.

core