Results 121 to 130 of about 4,135,250 (349)

Pragmatic Administrative Law and Tax Exceptionalism [PDF]

open access: yes, 2014
This Essay responds to the 2014 Duke Law Journal Administrative Law Symposium. Its principal contention is that courts and other commentators should give due weight to the history and virtues of the evolution of administrative law in the United States ...
Murphy, Richard
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Post-9/11 Illegal Immigrant Detention and Deportation: Terrorism and the Criminalization of Immigration

open access: yes, 2014
This paper analyzes the changes in immigration policy since the terrorist attacks of September 11, 2001 in terms of how immigrants are viewed in the United States.
Laun, Stefany N.
core  

A Biogeographic History of the Plains Bison Focusing on Population and Range Dynamics [PDF]

open access: yes, 2015
Early bison originated in Asia and migrated to North America by means of the Bering Land Bridge, which opened around 600,000 years ago. Just after the Wisconsin glaciation (11, 700 years ago), there were two allopatric species of bison residing in North ...
Roman, Grace
core   +2 more sources

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