Results 51 to 60 of about 2,258,944 (274)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Measurement and Evaluation of Efficiency. Criteria for Police Units [PDF]

Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2012
It is widely recognized that the exercise of the activity of management, as of all human activities, is not a purpose in itself, but rather a means to increase economic and social efficiency.
Ionica BOLEA, Gabriela DIMOFTE, George DIMOFTE   +2 more
doaj  

Gastric residual volume measurement in British neonatal intensive care units: a survey of practice

BMJ Paediatrics Open, 2020
Objective Despite little evidence, the practice of routine gastric residual volume (GRV) measurement to guide enteral feeding in neonatal units is widespread.
Jon Dorling, Chris Gale, Kerry Woolfall, Nazima Pathan, Elizabeth Deja, Lyvonne Tume, Izabela Andrzejewska, Barbara Arch, Lynne Latten, Louise Roper, Helen Eccleson, Helen Hickey, Michaela Brown, Anne Beissel, Frederic Valla   +14 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Measurement Units and Physical Dimensions of Fractance-Part II: Fractional-Order Measurement Units and Physical Dimensions of Fractance and Rules for Fractors in Series and Parallel

IEEE Access, 2016
Here and in the companion paper (Part I), a novel conceptual framework on the measurement units and physical dimensions of fractance and rules for fractors in series and parallel is mainly discussed.
Yi-Fei Pu
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Classification of Alpine Skiing Styles Using GNSS and Inertial Measurement Units

Sensors, 2020
In alpine skiing, four commonly used turning styles are snowplow, snowplow-steering, drifting and carving. They differ significantly in speed, directional control and difficulty to execute.
Christina Neuwirth, Cory Snyder, Wolfgang Kremser, Richard Brunauer, Helmut Holzer, Thomas Stöggl   +5 more
doaj   +1 more source

Diabetic microangiopathy in Type 1 (insulin-dependent) diabetic patients after successful pancreatic and kidney or solitary kidney transplantation [PDF]

, 1991
To evaluate the beneficial effect of pancreatic grafting on peripheral microcirculation and long-term clinical outcome, we compared data of 28 Type 1 (insulin-dependent) diabetic patients either given a pancreatic and kidney graft simultaneously or given
Abendroth, D., Illner, Wolf-Dieter, Land, Walter, Landgraf, R., Schmand, J.   +4 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source