Results 81 to 90 of about 2,258,944 (274)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Comparison of variant allele frequency and number of mutant molecules as units of measurement for circulating tumor DNA. [PDF]
Mol Oncol, 2021 Bos MK +11 more
europepmc +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
The measurement of low- and high-impact in citation distributions: technical results [PDF]
This paper introduces a novel methodology for comparing the citation distributions of research units working in the same homogeneous field. Given a critical citation level (CCL), we suggest using two real valued indicators to describe the shape of any ...
Ignacio Ortuno +2 more
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Performance Criterion of Phasor Measurement Units for Distribution System State Estimation
IEEE Access, 2019 A phasor measurement unit (PMU) is a device that can directly measure the phase angles of voltages and currents, with high accuracy, using accurate time signals.
Jonghoek Kim, Hyun-Tae Kim, Sungyun Choi
doaj +1 more source
Development of and flight results from the Space Acceleration Measurement System (SAMS) [PDF]
Described here is the development of and the flight results from the Space Acceleration Measurement System (SAMS) flight units used in the Orbiter middeck, Spacelab module, and the Orbitercargo bay.
Baugher, Charles R. +2 more
core +1 more source
Topology Detection in Microgrids with Micro-Synchrophasors
, 2015 Network topology in distribution networks is often unknown, because most switches are not equipped with measurement devices and communication links. However, knowledge about the actual topology is critical for safe and reliable grid operation. This paper
Andersson, Göran +5 more
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source