Results 81 to 90 of about 2,266,886 (292)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Direct high-precision measurement of the magnetic moment of the proton

, 2014
The spin-magnetic moment of the proton $\mu_p$ is a fundamental property of this particle. So far $\mu_p$ has only been measured indirectly, analysing the spectrum of an atomic hydrogen maser in a magnetic field. Here, we report the direct high-precision
A Mooser, A Mooser, A. Mooser, C. C. Rodegheri, C. Leiteritz, C. Smorra, CC Rodegheri, D Hanneke, DJ Wineland, DS Sivia, EA Cornell, G Gabrielse, H Häffner, H. Kracke, HG Dehmelt, J Beringer, J DiSciacca, J DiSciacca, J DiSciacca, J. Walz, K. Blaum, K. Franke, LS Brown, LS Brown, PF Winkler, R Bluhm, R Pohl, RK Mittleman, RS Van Dyck, RS Van Dyck Jr, S Sturm, S Sturm, S Ulmer, S Ulmer, S Ulmer, S. Ulmer, SG Karshenboim, W. Quint   +37 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Transient Stability Prediction for Real-Time Operation by Monitoring the Relative Angle with Predefined Thresholds

Energies, 2019
Under real-time operation, early detection of oscillations that lead to instability is of noteworthy importance for power system operators. This paper demonstrates how the relative angle (RA) obtained with online data from phasor measurement units (PMUs)
A. F. Diaz-Alzate, John E. Candelo-Becerra, Juan F. Villa Sierra   +2 more
doaj   +1 more source

Comparison of variant allele frequency and number of mutant molecules as units of measurement for circulating tumor DNA. [PDF]

Mol Oncol, 2021
Bos MK, Nasserinejad K, Jansen MPHM, Angus L, Atmodimedjo PN, de Jonge E, Dinjens WNM, van Schaik RHN, Del Re M, Dubbink HJ, Sleijfer S, Martens JWM.   +11 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The measurement of low- and high-impact in citation distributions: technical results [PDF]

This paper introduces a novel methodology for comparing the citation distributions of research units working in the same homogeneous field. Given a critical citation level (CCL), we suggest using two real valued indicators to describe the shape of any ...
Ignacio Ortuno, Javier Ruiz-Castillo, Pedro Albarran   +2 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Performance Criterion of Phasor Measurement Units for Distribution System State Estimation

IEEE Access, 2019
A phasor measurement unit (PMU) is a device that can directly measure the phase angles of voltages and currents, with high accuracy, using accurate time signals.
Jonghoek Kim, Hyun-Tae Kim, Sungyun Choi
doaj   +1 more source