Results 91 to 100 of about 2,132,437 (321)
United We Stand: Platforms, Tools and Innovation With the Unity Game Engine
Social Media + Society, 2019 The skirmish between game engines Unity and Unreal presents a new front in the platformization of cultural production. This article argues that such programs are “platform tools.” They enable amateurs and professionals to not only build content for ...
Maxwell Foxman
semanticscholar +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Case Reports in Pulmonology, 2020 Postpartum pulmonary hypertension (PPPHT) is an extremely rare disorder, with few reported cases. Late diagnosis and treatment are associated with significant morbidity and mortality.
Mahmood Mubasher +8 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Canadian Geriatrics JournalWe evaluated the validity of using the CanMEDS Resident as Teacher Multisource Feedback (RaTMSF) assessment tool to gather learner feedback from structured resident-led teaching within the University of Toronto’s postgraduate geriatric medicine ...
Janice C.L. Lee +2 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Don\u27t Fall for the Lies Behind Trump\u27s Calls for Unity
, 2017 Each summer, more than half a million tourists come to Gettysburg, a battlefield in the most divisive conflict in American history. After marching around in the heat, thousands stop in at Mr. G’s for some of the best ice cream in town.
Hancock, Scott
core
Assessing the Role of the ‘Unity Assumption’ on Multisensory Integration: A Review
Frontiers in Psychology, 2017 There has been longstanding interest from both experimental psychologists and cognitive neuroscientists in the potential modulatory role of various top–down factors on multisensory integration/perception in humans.
Yi-Chuan Chen, C. Spence
semanticscholar +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source