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Więcej, bardziej, pełniej. Emigracja według Tomasza Łychowskiego

Postscriptum Polonistyczne, 2020
The aim of the article is to describe the way in which Tomasz Łychowski defines the phenomenon of emigration in his poems from the volume Spojrzenia (Glances, 2016).
Magdalena Bąk
doaj

The Gradation and Unity of Existence and its Impact on Human Worldview from the Perspective of Revelational and Rational Arguments [PDF]

International Multidisciplinary Journal of Pure Life
SUBJECT & OBJECTIVES: There are two main theories about the reality of existence discussed in Islamic philosophy and mysticism, namely the Gradation of Existence and the Unity of Existence.
Syed Abbas Hosseini +2 more
doaj +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source

Multiplicity dependence of K*(892) ±  production in pp collisions at s=13 TeV

Physics Letters B
The first results of K*(892) ±  production at midrapidity (|y| 
I.J. Abualrob +1067 more
doaj +1 more source

The Principle of Causality and Its Place in the Philosophy of Avicenna and Sadra's Wisdom [PDF]

حکمت سینوی
The issue of causality and the question of why things happen are among the first issues that have made every thinker ponder. Avicenna and Mulla Sadra, as two philosophers committed to the principle of causality, have dealt with this issue in detail ...
Kokab Darabi +2 more
doaj +1 more source

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