Mulla Sadra has been accused of electing two different conceptual schemes of philosophy and mysticism. However, it can be said that he reconstructed and redefined fundamental philosophical concepts in light of mystical doctrines. In this view, he replaced gradation of being with gradation of manifestations of Being and instauration with theophany and ...
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Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Valley-Dependent Topological Interface States in Biased Armchair Nanoribbons of Gapless Single-Layer Graphene for Transport Applications. [PDF]
Huang ZH, Lai JY, Wu YS.
europepmc +1 more source
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Self-learning virtual organisms in a physics simulator: on the optimal resolution of their visual system, the architecture of the nervous system and the computational complexity of the problem. [PDF]
Zenin MS, Devyaterikov AP, Palyanov AY.
europepmc +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Information thinking: the transformation of complexity and scientific thinking. [PDF]
Wu T, Zhang H, Wu K.
europepmc +1 more source
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Normalized Caputo-Fabrizio SVIR modeling and bifurcation analysis. [PDF]
Shafqat R +3 more
europepmc +1 more source
A Criterion for the Existence of the Twosided Unity Element of Semigroups
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