Results 61 to 70 of about 166,543,721 (283)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Presentation at the Fifth Ordinary Session of the Council of Ministers of the various recommendations submitted by the Organization of African Unity Specialised Commissions concerning their studies of the various aspects of the elements of African Unity bearing in mind Ghana's proposal aiming at the "Establishment of a Union Government of Africa"

, 1965
Council of Ministers, Fifth Ordinary Session, Accra, October 1965Study and proposal of the Organization of African Unity Specialized Commissions to the Council of Ministers on the various aspects of the elements of African Unity, including solidarity ...
Organization of African Unity
core   +1 more source

Draft Financial Rules and Regulations of the Organization of African Unity

, 1978
This report contains the draft financial rules and regulations to be applied to the budget and financial management of the Organization of African Unity and all its ...
Organization of African Unity
core   +1 more source

The effects of recreational cannabis use on glycemic outcomes and self-management behaviours in people with type 1 and type 2 diabetes: a rapid review

Systematic Reviews, 2020
Background Recent surveys of Canadian cannabis users reflect increasing consumption rates, some of whom may have diabetes. However, healthcare providers have limited information resources on the effects of recreational cannabis in people with diabetes ...
Caroline J. Porr, Patricia Rios, Harpreet S. Bajaj, Aoife M. Egan, Celine Huot, Ryan Batten, Lisa Bishop, Devonne Ryan, Erin Davis, Nazia Darvesh, Arifur Rahman, Shabnam Asghari, Lily Acheampong, Andrea C. Tricco   +13 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Statement of Outstanding Contributions Due to Regular Budgets of the Organization of African Unity as at 31st January 1984 [PDF]

, 1984
Council of Ministers Fortieth Ordinary 'Session Addis Ababa, Ethiopia 27 February - 7 March, 1984This is a detailed statement of outstanding contributions due to the regular budgets of the Organization of African Unity as at 31 January ...
Organization of African Unity
core   +1 more source

Application for Subvention for the Financial Year 1980/81 by the Organization of African Trade Union Unity

, 1980
Council of Ministers Thirty-Fourth Ordinary Session, February 1980A report on the application for subvention from the Organization of African Unity by the Organization of African Trade Union Unity with highlights on its activities and it ...
Organization of African Unity
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source