Results 241 to 250 of about 5,502,919 (295)

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

RECQ4 restricts non-interfering crossover formation to fine-tune meiotic recombination rates in rice. [PDF]

Plant Biotechnol J
Li Y, You H, Cheng X, Wang B, Zhao Y, Chen J, Cao L, Wen M, Zhang Y, Chen Z, Luo Q, Cheng Z.   +11 more
europepmc   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Differential subordination and superordination results for p-valent analytic functions associated with (r,k)-Srivastava fractional integral calculus. [PDF]

MethodsX
Tayyah AS, Atshan WG.
europepmc   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

Molecular Interactions of Viral Insulin/IGF‐Like Peptides With Zebrafish Receptors

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Signaling through the insulin receptor (IR) and the type 1 insulin‐like growth factor receptor (IGF1R) is modulated by secreted hormones and growth factor ligands (e.g., insulin and insulin‐like growth factor 1, IGF1). Impaired signaling in these receptors often leads to diabetes and oncogenic diseases.
Lev Levintov, Harish Vashisth
wiley   +1 more source

Loss of E3 ligase HvST1 function substantially increases distal crossover frequency. [PDF]

New Phytol
Orr JN, Mittmann SU, Ramsay L, Lewandowska D, Barakate A, Macaulay M, McCallum N, Waugh R, Colas I.   +8 more
europepmc   +1 more source

The underappreciated, underrecognized problem of fourth chromosome trisomy in <i>Drosophila melanogaster</i> stocks and a simple, general method for building diplo-4 stocks from triplo-4 stocks. [PDF]

MicroPubl Biol
Cook KR.
europepmc   +1 more source

The HORMA-domain protein ASY1 recruits the plant-specific cyclin SDS to promote DMC1-mediated meiotic recombination. [PDF]

Plant Cell
Cai B, Yuan X, Cao F, Luo Y, Zhang Y, Zhuang J, Geng M, Chu L, Schnittger A, Yang C.   +9 more
europepmc   +1 more source

The Meiotic Spindle, Mechanisms of Chromosome Segregation and Aneuploidy in Aging Human Oocytes: An Update Review. [PDF]

Medicina (Kaunas)
Sciorio R, Teglas G, Tramontano L, Nanassy L, Girardi L, Fleming S.   +5 more
europepmc   +1 more source