Results 241 to 250 of about 3,084,757 (296)

The Random Soldier Kinematogram: a novel tool for task-switching research in military context. [PDF]

Front Psychol
Mecheri S, Gouasmi W, Dozias B, Lobjois R.   +3 more
europepmc   +1 more source

Designing Thermally Stable DNA Hydrogels via Entropically‐Driven Acridine Intercalation

Macromolecular Rapid Communications, EarlyView.
Environmental variables are shown to systematically tune the network dynamics of entropy‐driven, acridine‐based DNA‐intercalating supramolecular hydrogels. Adjusting the buffer composition, ionic identity, and salt concentration impacts electrostatic screening and counterion release of the DNA backbone, offering a powerful handle to tune elasticity and
Shaina M. Hughes, Amy M. DiVito, Patrick F. Strobel, Pearson J. J. Franz, Matthew E. Currier, Nathan J. Oldenhuis   +5 more
wiley   +1 more source

RECQ4 restricts non-interfering crossover formation to fine-tune meiotic recombination rates in rice. [PDF]

Plant Biotechnol J
Li Y, You H, Cheng X, Wang B, Zhao Y, Chen J, Cao L, Wen M, Zhang Y, Chen Z, Luo Q, Cheng Z.   +11 more
europepmc   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Epigenetic deciphering of ovarian aging: multilayer interactive mechanisms and targeted reversal strategies. [PDF]

Epigenetics Chromatin
Zhang Y, Yang Y, Liao Q, Chen X, Wang K, Zhang R, Li J, Liu H.   +7 more
europepmc   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Epigenetic histone H3 phosphorylation marks discriminate between univalent- and bivalent-forming chromosomes during canina asymmetrical meiosis. [PDF]

Ann Bot
Kalfusová R, Herklotz V, Kumke K, Houben A, Kovařík A, Ritz CM, Lunerová J.   +6 more
europepmc   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source