Results 181 to 190 of about 2,827,055 (299)

Modulation of Epigenetic Control by Advanced Molecular Tweezers

open access: yesChemistry – A European Journal, EarlyView.
Tailored dimeric molecular tweezers recognize the DNA‐binding part of Histone H4 and interrupt the essential histone‐DNA interaction. ABSTRACT This work addresses the question if supramolecular systems can be tailored to interfere with posttranslational modifications (PTM) and epigenetics.
My‐Hue‐Le   +9 more
wiley   +1 more source

Controlling Structures and Properties of NaCl‐Containing Alginate/Polyacrylamide Tough Hydrogels via a One‐Pot Process

open access: yesChemistry – A European Journal, EarlyView.
NaCl‐incorporated alginate/polyacrylamide tough hydrogels are prepared through a facile one‐pot strategy that enables direct ion incorporation during network formation. Compared with conventional soaking, this approach reduces diffusion‐limited ion gradients and provides a more spatially consistent ion distribution.
Taeuk Eom   +6 more
wiley   +1 more source

Two‐Coordinate 13‐Electron PdI Complexes Stabilized by the Bulky DIMeIHeptCl NHC Ligand

open access: yesChemistry – A European Journal, EarlyView.
Bulky N‐heterocyclic carbene (NHC) ligand DiMeIHeptCl stabilizes rare two‐coordinate 13‐electron PdI species. These monomeric complexes are directly observed crystallographically and by electron paramagnetic resonance (EPR) spectroscopy, and display unusual structures and radical‐type reactivity, forming Pd0(NHC) via Pd─X bond homolysis or ...
Volodymyr Semeniuchenko   +8 more
wiley   +1 more source

Trends and Future Directions in Organic Chemistry for Drug Discovery

open access: yesChemistry – A European Journal, EarlyView.
Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley   +1 more source

Alkali Metal Mediated Redox Tuning in Bis(μ‐OH) Dinickel(II) Complexes

open access: yesChemistry – A European Journal, EarlyView.
Alkali metal ions are ubiquitous in both enzymatic and synthetic catalytic media. The present study highlights the powerful influence common monocations have on the structural and electrochemical properties of catalytically relevant bis(μ‐hydroxo) dinickel diamond cores, through a well‐defined series of heterometallic clusters (Li+, Na+, K+, and Cs ...
Matthew L. Peris, Joshua A. Buss
wiley   +1 more source

Photochemical Generation and Spectroscopic Characterization of Parent 3‐Iminooxetane and 3‐Oxazoline From 3‐Azidooxetane

open access: yesChemistry – A European Journal, EarlyView.
Two previously uncharacterized heterocyclic imines, 3‐iminooxetane and 3‐oxazoline, are generated simultaneously by irradiation of 3‐azidooxetane under matrix isolation conditions. The infrared spectra provide reference data for future gas‐phase studies and may facilitate their search in the interstellar medium.
Mika Maehara   +4 more
wiley   +1 more source

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