Results 231 to 240 of about 536,183 (317)

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

open access: yesChronic Diseases and Translational Medicine, EarlyView.
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin   +5 more
wiley   +1 more source

Genotoxicity, DNA damage and sperm defects induced by vinblastine. [PDF]

open access: yesMol Biol Rep, 2023
Fahmy MA   +3 more
europepmc   +1 more source

Alcohol and Carbonyl Redox Reactions in Electrochemical Organic Synthesis

open access: yesChemistryEurope, EarlyView.
This review aims to provide the reader with a useful tool to deal with electrochemical redox reactions involving alcohols and carbonyl compounds. The review is organized in an accessible format and divided into sections that focus on key parameters of wide‐ranging electrosynthetic methods.
Fiammetta Vitulano   +5 more
wiley   +1 more source

Unveiling New Triazoloquinoxaline‐Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9

open access: yesChemistry – A European Journal, EarlyView.
We present new BRD9‐targeting degraders featuring a chemical warhead and E3 ligase ligand that distinctly differ from the typical chemical units used for BRD9 degradation. Specifically, we identified two VHL‐based PROTACs (2 and 9) based on a [1,2,4]triazolo[4,3‐a]quinoxaline scaffold that effectively and selectively degrade BRD9 and exhibit ...
Martina Pierri   +15 more
wiley   +1 more source

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