Results 41 to 50 of about 215,946 (262)
Mathematics, 2022 The outcome of a dimensionless characterization study in a two-dimensional porous media domain in which groundwater flows at a constant horizontal velocity is presented in this report.
José Antonio Jiménez-Valera +1 more
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Universality of slip avalanches in flowing granular matter
Nature Communications, 2016 Whether the deformation of amorphous materials is governed by universal scaling, a characteristic feature of the critical phenomena, is currently under debate. Here, Denisov et al.
D. V. Denisov +4 more
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Universal adhesives - a new direction in the development of adhesive systems
Česká Stomatologie a Praktické Zubní Lékařství, 2020 Objectives: In the past decade, many new adhesive systems labeled as universal were introduced. Their common characteristic is that they can be applied to hard dental tissues either in self-etch or etch-and-rinse mode, and they are also able to bond to ...
A. Tichý, K. Hosaka, J. Tagami
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Jixie chuandong, 2002 This paper focuses on the method of solving the non-linear equation arising form the synthesis of plane rigid guidance. Based on the concept of universal Grey number and the rules of four algebraic operation of universal Grey number,it is introduced ...
罗佑新 +3 more
doaj
Formation of universal learning activities of younger schoolchildren as a pedagogical problem
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2018 Formation of universal learning activities in the system of elementary education as a pedagogical problem is considered. The bases of “universal learning activities” notion are revealed.
Y. P. Prokudin, E. A. Мilenko
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source