Results 41 to 50 of about 227,956 (262)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Universality of slip avalanches in flowing granular matter
Nature Communications, 2016 Whether the deformation of amorphous materials is governed by universal scaling, a characteristic feature of the critical phenomena, is currently under debate. Here, Denisov et al.
D. V. Denisov +4 more
doaj +1 more source
Universal adhesives - a new direction in the development of adhesive systems
Česká Stomatologie a Praktické Zubní Lékařství, 2020 Objectives: In the past decade, many new adhesive systems labeled as universal were introduced. Their common characteristic is that they can be applied to hard dental tissues either in self-etch or etch-and-rinse mode, and they are also able to bond to ...
A. Tichý, K. Hosaka, J. Tagami
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Jixie chuandong, 2002 This paper focuses on the method of solving the non-linear equation arising form the synthesis of plane rigid guidance. Based on the concept of universal Grey number and the rules of four algebraic operation of universal Grey number,it is introduced ...
罗佑新 +3 more
doaj
Formation of universal learning activities of younger schoolchildren as a pedagogical problem
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2018 Formation of universal learning activities in the system of elementary education as a pedagogical problem is considered. The bases of “universal learning activities” notion are revealed.
Y. P. Prokudin, E. A. Мilenko
doaj +1 more source
Universalities of earthquake-network characteristics [PDF]
Chinese Science Bulletin, 2011 The scale-free and small-world properties are studied in detail for the complex earthquake networks constructed from the seismic data sets taken from California (USA), Japan, Iran and Chile. It is found that, in all these geographical regions, both the exponent γ of the power-law connectivity distribution and the clustering coefficient C take the ...
Abe, Sumiyoshi +3 more
openaire +4 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source