Results 71 to 80 of about 1,204,045 (278)

On the universal deformations for SL_2-representations of knot groups

open access: yes, 2017
Based on the analogies between knot theory and number theory, we study a deformation theory for SL_2-representations of knot groups, following after Mazur's deformation theory of Galois representations.
Morishita, Masanori   +3 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Characteristics of Handball in University Sports

open access: yesPedagogical Almanac, 2022
This article focuses on the development and implementation of a new vision for the development of physical education and sports in the Republic of Bulgaria. Both nationally and regionally, opportunities are expanded and conditions are created for a new national policy in the field of physical education and sports, tailored to the interests and ...
openaire   +1 more source

Universalities of earthquake-network characteristics [PDF]

open access: yesChinese Science Bulletin, 2011
The scale-free and small-world properties are studied in detail for the complex earthquake networks constructed from the seismic data sets taken from California (USA), Japan, Iran and Chile. It is found that, in all these geographical regions, both the exponent γ of the power-law connectivity distribution and the clustering coefficient C take the ...
Abe, Sumiyoshi   +3 more
openaire   +4 more sources

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

UNIVERSAL GREASING AND MODIFICATING SUBSTANCE FOR FOUNDRY AND METAL-WORKING PRODUCTION

open access: yesЛитьë и металлургия, 2005
The characteristic of new universal lubricating and modifying stuff for foundry and metal-working production is given in the article.
A. A. Klyshko
doaj  

A NEW VARIETY OF CUCURBITA FICIFOLIA «IN HONOR OF MEMORY TARAKANOV»

open access: yesОвощи России, 2016
The characteristic of the new variety of Cucurbita ficifolia (Cucurbita ficifolia Bouche.), «In honor of Memory Tarakanov», is provided. The variety is mid ripening, the yield of marketable fruits is 16,0-22,0 t / ha.
G. A. Starich   +2 more
doaj   +1 more source

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