ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Addressing Weight Stigma in Libraries to Promote Diversity, Equity and Inclusion
In the Library with the Lead PipeIn Brief: The goal of this paper is to help librarians understand why weight stigma and discrimination are pervasive, the impact they have on people, what interventions have been tried to reduce or prevent weight stigma, and what librarians can do to ...
Lorelei Rutledge +2 more
doaj
Adapting Polish apartments to the needs of older people
Medycyna PracyBackground The construction of postwar housing in Poland does not meet the quantitative and qualitative needs of society. There is a shortage of thousands of apartments.
Przemysław Nowakowski
doaj +1 more source
Development of Aerobic Exercise Equipment Using Universal Design: Treadmill and Arm Ergometer. [PDF]
Healthcare (Basel), 2022 Yi E, Byun H, Oh A.
europepmc +1 more source
Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez +10 more
wiley +1 more source
Enhancing the online student experience through the application of Universal Design for Learning (UDL) to research methods learning and teaching. [PDF]
Educ Inf Technol (Dordr), 2023 Seymour M.
europepmc +1 more source
MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru +13 more
wiley +1 more source
Transmedia storytelling usage of neural networks from a Universal Design for Learning perspective: A systematic review. [PDF]
Front Psychol, 2023 Meyerhofer-Parra R +1 more
europepmc +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
RETRACTED: Universal Design for Learning for Children with ADHD.
Children (Basel), 2023 Frolli A +5 more
europepmc +1 more source