Results 51 to 60 of about 245,016 (254)

Mitolojik Kadın Ktisteslere Bir Örnek Olarak Sinope

Journal of Universal History Studies, 2020
Bugüne kadar elde edilen epigrafik ve arkeolojik veriler, antik kentlerin kuruluşunda mitolojik hikayelerin önemli bir yerinin olduğunu göstermektedir.
Nazli Yıldırım
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Osmanlı İmparatorluğu’nda Bakır Madenleri (1453-1789)

Journal of Universal History Studies, 2019
Osmanlı toplumunda saraydan, dini mekânlara, sosyal müesseselerden harp aletlerine kadar toplumun her tabakasında bakır madenleri revaçtadır. Osmanlı ordusunda kullanılan topların hammaddesi olarak stratejik bir öneme haiz olan bakır madenleri, devletin ...
Erdem Saka
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

1271 (1855) Tarihli Kayseri Kazasına Ait Yoklama Defterinin Tanıtımı ve Tahlili

Journal of Universal History Studies, 2020
KAYTAM Arşivinde bulunan ve 3718 numarada kayıtlı 13 Mayıs 1855’den 13 Eylül 1855 tarihine kadara dört aylık zaman içerisinde Kayseri merkez mahalle ve köyleri ile Kayseri’ye bağlı Develi, Zamantı kazalarına bağlı köylerde vefat eden ve yeni doğan ...
Hava Selçuk
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Sleep Paralysis from the Viewpoint of Persian Medicine

Traditional and Integrative Medicine
Sleep paralysis, described as Kabus in Persian medicine (PM), is a state during sleep in which a person senses heaviness on the chest without the ability to speak or move. This study aims to review sleep paralysis from the viewpoint of Persian medicine.
Mahdie Hajimonfarednejad, Babak Daneshfard, Mohammad Javad Raee, Dennis Cordato, Mohammad Mahdi Parvizi, Mohadeseh Ostovar   +5 more
doaj   +1 more source

Osmanlı’da Sinema Yayıncılığı ve Bilinen İlk Türkçe Sinema Gazetesi: Türk Sineması

Journal of Universal History Studies, 2019
Osmanlı’da ilk Türkçe sinema gazeteleri 1914’te yayın hayatına girmiştir. Bununla birlikte Osmanlı dönemi sinema yayıncılığı ve yayınları az çalışılmış bir konudur ve bu nedenle büyük oranda meçhul kaldığı söylenebilir.
İsmail Arda Odabaşı
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source