Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru +13 more
wiley +1 more source
Protocolos clínicos para los adhesivos universales [PDF]
, 2017 El avance de las tecnologías en los materiales restauradores busca no solo un mayor rendimiento clínico, sino también la simplicidad en la técnica y aplicación de los mismos.
De Andrea, Antonela +6 more
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Universal adhesives applied to deep dentin with different bonding treatments. [PDF]
Acta Odontol Latinoam, 2022 Mirotti G +8 more
europepmc +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen +6 more
wiley +1 more source
¿Confieren poderes causales los universales trascendentes?
, 2016 Este trabajo discute el así llamado argumento 'eleático' en contra de la existencia de universales trascendentes, esto es, universales que no requieren de la instanciación para su existencia.
Alvarado Marambio, José Tomás
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Sobre la crítica y las ediciones de textos en la jurisprudencia humanística [PDF]
, 2008 Troje, Hans Erich
core +1 more source
Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay +15 more
wiley +1 more source
Universales atributivos de la filosofía helénica antigua : Eíde, Tópoi y Lektá [PDF]
, 2012 In this paper we defend that Hellenistic philosophy has created two fundamentals: scientific truths and the physical-rational being. Now, to avoid dogmatisms, they have to be understood as accumulative universals.
Pérez Herranz, Fernando Miguel
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