Results 41 to 50 of about 119,582 (299)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

COSMOS2020: A Panchromatic View of the Universe to z ∼ 10 from Two Complementary Catalogs [PDF]

, 2022
John R. Weaver, O. B. Kauffmann, O. Ilbert, H. J. McCracken, A. Moneti, Sune Toft, Gabriel Brammer, Marko Shuntov, I. Davidzon, Bau-Ching Hsieh, C. Laigle, Α. Αναστασίου, Christian Kragh Jespersen, J. Vinther, P. Capak, Caitlin M. Casey, Conor McPartland, B. Milvang‐Jensen, Bahram Mobasher, D. B. Sanders, L. Zalesky, S. Arnouts, H. Aussel, J. S. Dunlop, Andreas L. Faisst, Marijn Franx, Lukas J. Furtak, J. P. U. Fynbo, Katriona M. L. Gould, T. R. Greve, Stephen Gwyn, Jeyhan S. Kartaltepe, Daichi Kashino, Anton M. Koekemoer, Vasily Kokorev, O. Le Fèvre, S. J. Lilly, Daniel Masters, G. Magdis, Vihang Mehta, Yingjie Peng, Dominik A. Riechers, M. Salvato, Marcin Sawicki, Claudia Scarlata, N. Z. Scoville, R. Shirley, J. D. Silverman, Albert Sneppen, V. Smolčić, Charles L. Steinhardt, Daniel Stern, Masayuki Tanaka, Yoshiaki Taniguchi, Harry I. Teplitz, M. Vaccari, Wei-Hao Wang, G. Zamorani   +57 more
openalex   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

İnsan, Kâinat ve Yaratılış Ekseninde Hallâc-ı Mansûr’un Tevhid Düşüncesinin Felsefî Analizi

Kocaeli İlahiyat Dergisi, 2023
ÖzKâinat ve insanın varoluşunu inceleyen ilim dallarının bu kavramları farklı pers-pektif ve yorumlarla açıkladığını, neden-sonuç ilişkisini fizik ve metafizik bağlamlarda ele aldıklarını görmekteyiz. Bu ilim dallarından tefsir, hadis, felsefe, psikoloji,
Emine Elif Çakmak İgalçı
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Have pulsar timing arrays detected the hot big bang: Gravitational waves from strong first order phase transitions in the early Universe [PDF]

, 2022
Katherine Freese, Martin Wolfgang Winkler   +1 more
openalex   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Reconstructing the Universe [PDF]

Physical Review D, 2005
52 pages, 20 postscript figures, added ...
Ambjørn, Jan, Jurkiewicz, Jerzy, Loll, R.   +2 more
openaire   +6 more sources