Results 51 to 60 of about 113,830 (296)
THEORIA. An International Journal for Theory, History and Foundations of Science, 2014 In (Béziau 2001), Béziau provides a means by which Gentzen s sequent calculus can be combined with the general semantic theory of bivaluations. In do- ing so, according to Béziau, it is possible to construe the abstract "core" of logics in general, where logical syntax and semantics are "two sides of the same coin". The central suggestion there is that,
openaire +7 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Political Necissities of the Goal-oriented Universe from the Perspective of the Holy Quran [PDF]
پژوهش نامه معارف قرآنی, 2018 The study of the position of the Universe as the material world has a special significance in its purposefulness or instrumentalism in politics. The question is that whether acquiring different dimensions of Universe is the purpose of politics, or it is ...
mohammad abedi
doaj +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Теорія і практика правознавства, 2019 The knowledge of the Universe is an integral part of understanding of human nature. People can perceive themselves, their nature, essence, relations with other people only through learning and understanding the world, the laws of evolution and existence.
Valentina Petrovna Simonok
doaj +1 more source
St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2021 A modification of the covariant theory based on the concept of the proper mass (mass distribution) of the system is proposed. The proper mass is a special dynamic quantity that forms a fundamental frame of reference for measuring proper time and spatial
Gorobey Natalia +2 more
doaj +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source