Results 21 to 30 of about 12,136,781 (304)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla   +10 more
wiley   +1 more source

LA UNIVERSIDAD NERD [PDF]

open access: yesRevista chilena de literatura, 2013
Las universidades son, desde el siglo XIII europeo, y desde las postrimerías de la era colonial en América, el reino oficial u oficializado del conocimiento. Fueron mayormente públicas, hoy ya no, y las fronteras que antes había entre lo público y lo privado se han hecho borrosas.
openaire   +3 more sources

EAFIT y Augura recibieron nueva patente que favorece salud de los cultivos agrícolas [PDF]

open access: yes, 2021
La nueva patente de invención para EAFIT (la número 58 de la Universidad) y para la Asociación de Bananeros de Colombia (Augura) es un proceso biotecnológico para el desarrollo de nuevos antibióticos que podrían servir para combatir ...
Revista Universidad EAFIT   +1 more
core  

SPG4 and Dementia: Expanding the Clinical Spectrum

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza   +19 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio   +8 more
wiley   +1 more source

Acuerdos de movilidad de estudiantes ERASMUS y SICUE.Curso 2022-2023. Universidad de Zaragoza

open access: yes, 2023
Plazas asignadas a los alumnos OUT recoge el número total de plazas de movilidad de acuerdos ERASMUS o SICUE que han sido asignadas a estudiantes de la UZ para realizar estancias en otras Universidades.
Universidad de Zaragoza
core  

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes   +75 more
wiley   +1 more source

¿SON UNIVERSIDADES TODAS LAS UNIVERSIDADES? LA UNIVERSIDAD COMO COMUNIDAD ÉTICA

open access: yesBordón. Revista de Pedagogía, 2012
ESP
Esteban Bara, Francisco   +1 more
openaire   +2 more sources

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