Results 31 to 40 of about 3,662,287 (300)

Analysis of cosmic ray variations observed by the CARPET in association with solar flares in 2011-2012 [PDF]

, 2013
The CARPET cosmic ray detector was installed on April 2006 at CASLEO (Complejo Astronmico El Leoncito) at the Argentinean Andes (31.8S, 69.3W, 2550 m, Rc=9.65 GV).
Bazilevskaya, G. A., Correia, E., De Mendonca, R. R. S., Echer, E., Fernandez, German Enzo Leonel, Kaufmann, Pierre, Makhmutov, V., Marun, Adolfo Hector, Raulin, J. P.   +8 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Exploring RNA-targeted gene therapy approaches for hypertrophic cardiomyopathy [PDF]

, 2012
Relatório de projeto no âmbito do Programa de Bolsas Universidade de Lisboa/Fundação Amadeu Dias (2011/2012). Universidade de Lisboa.
Freitas, Ana
core  

Dibucaine in Ionic-Gradient Liposomes: Biophysical, Toxicological, and Activity Characterization [PDF]

, 2018
Administration of local anesthetics is one of the most effective pain control techniques for postoperative analgesia. However, anesthetic agents easily diffuse into the injection site, limiting the time of anesthesia. One approach to prolong analgesia is
Alonso, Silvia del Valle, Castro, Simone R., Couto, Verônica M., Dantzger, Darlene D., de Paula, Eneida, Feas, Daniela Agustina, Guilherme, Viviane A., Igartúa, Daniela, Machado, Daisy, Prieto, Maria Jimena, Ribeiro, Lígia N.M., Silva, Camila M.G.   +11 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

DIVERSIDADE CULTURAL, RELAÇÕES RACIAIS E EDUCAÇÃO NA UNEMAT

Revista da Faculdade de Educação (Universidade do Estado de Mato Grosso), 2019
Este artigo traz uma reflexão sobre as disciplinas ministradas na Universidade do Estado de Mato Grosso no Curso de Graduação-Licenciatura em Pedagogia, Campus de Juara e no Curso de Pós-Graduação “Docência no Ensino Superior”, Campus de Sinop.
Ivone Jesus Alexandre
doaj  

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Anais do I Congresso Sergipano Multiprofissional de Oncologia (COSMO)

Revista Brasileira de Cancerologia, 2020
Nos dias 8 e 9 de novembro, o I Congresso Sergipano Multiprofissional de Oncologia (COSMO) aproximou acadêmicos e profissionais, clínicos e pesquisadores, sociedade e gestão para cuidado humanizado do paciente oncológico. Nessa perspectiva, foi de grande
Universidade Federal de Sergipe
doaj   +1 more source

Geochemical constraints on the Hadean environment from mineral fingerprints of prokaryotes [PDF]

, 2017
The environmental conditions on the Earth before 4 billion years ago are highly uncertain, largely because of the lack of a substantial rock record from this period.
Abrevaya, Ximena Celeste, Chaffin, Michael S., Conti, Maria Josiane, Navarro, Margareth Sugano, Novoselov, Alexey A., Schneider, Jerusa, Serrano, Paloma, Silva, Dailto, Souza Filho, Carlos Roberto de   +8 more
core   +1 more source