Results 161 to 170 of about 3,650,943 (307)
Revista de la Facultad de Medicina, 1939 La interpretación de la norma universitaria, es la de que la institución debe acomodarse al medio, es decir: desarrollar la inteligencia de las generaciones imprimiéndoles un carácter de conjunto y de aplicación de las enseñanzas, adaptándolas al adelanto de la sociedad en que se vive, para redimir al hombre de la ignorancia, civilizarlo, capacitarlo ...
openaire +2 more sources
A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation
Advanced Science, EarlyView.A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu +7 more
wiley +1 more source
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
MERCANTILIZAÇÃO DA UNIVERSIDADE
Perspectivas Online: Humanas e Sociais Aplicadas, 2015 Este trabalho é resultado parcial da pesquisa de dissertação que analisa o papel da Universidade (sobretudo a pública), no novo modo de produção de conhecimento, onde tais instituições estão cada vez mais interligadas às empresas privadas e ao governo ...
MATTOS, R. F. K.
doaj
First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, EarlyView.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
Revista Espaço Acadêmico, 2009 Ainda não se discutiu suficientemente sobre os limites do conhecimento científico e da capacidade dos cientistas. A ciência jamais foi eficaz o bastante para expressar a densidade da vida, os sentimentos envolvidos em um olhar, o olhar sobre o outro e ...
Walter Lúcio de Alencar Praxedes
doaj
Advanced Science, EarlyView.Inspired by the mimosa, this study develops a flexible triboelectric nanogenerator with a novel microneedle array and battery‐mimetic architecture. The device introduces a spontaneous charge self‐regulation mechanism that confines the electric field below the air breakdown threshold, and achieves an outstanding charge density of 396.50 µC m−2 ...
Hanpeng Gao +7 more
wiley +1 more source
Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity
Advanced Science, EarlyView.This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao +11 more
wiley +1 more source
Universidade de Coimbra; Universidade da Beira Interior; Universidade do Minho [PDF]
Boletim da Sociedade Portuguesa de Química, 1994 openaire +1 more source
Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound
Advanced Science, EarlyView.Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García +11 more
wiley +1 more source