Results 261 to 270 of about 40,229,784 (363)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera +11 morewiley +1 more sourceAssociation of leukocyte count with death in people with HIV: A longitudinal study over 24 years. [PDF]
PLoS OneKlein Z, Meyer SC, Schoepf IC, Weber M, Thorball CW, Ryom L, Kootstra NA, Reiss P, Braun DL, Thurnheer MC, Marzolini C, Kahlert CR, Bernasconi E, Cavassini M, Marinosci A, Fellay J, Kouyos RD, Günthard HF, Ledergerber B, Tarr PE, and the Swiss HIV Cohort Study. +20 moreeuropepmc +1 more sourceTumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini +12 morewiley +1 more sourceThe neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal +8 morewiley +1 more sourceAddressing Commercial Health determinants: Indigenous Empowerment and Voices for Equity (ACHIEVE)-protocol for a multiphase study. [PDF]
BMJ OpenCubillo Larrakia/Wadjigan BJ, Browne J, Sherriff S, Walker Yorta Yorta T, Hill K, Crocetti A, Mitchell F, Backholer K, Maddox R, Brown A, Allender S, Wright CJC, Lacy-Nichols J, Chamberlain C, Ropitini Ngāti Kahungunu/Ngāti Maniapoto Iwi/Trawlwoolway A, Taylor N, Blair N, Richards G, Huxley RR, Ananthapavan J, Hedges J, Poirier B, Peeters A, Nguyen P, Swinburn B, Atkinson-Briggs S, Yeomans L, Paradies Y. +27 moreeuropepmc +1 more sourceSelf-medication of antibiotics: investigating practice among university students at the Malaysian National Defence University
, 2019 M Haque, Rahman NAA, J McKimm, Kibria GM, Md Anwarul Azim Majumder, Haque SZ, Islam MZ, Binti Abdullah SL, Daher AM, Zulhafizsyam Bin Zulkifli, Shahreen Rahman, Rabeya Kabir, Lutfi SNNB, Aishah Binti Othman NS +13 moreopenalex +1 more source