Results 31 to 40 of about 29,574,253 (245)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The European Physical Journal C, 2018 We present a unified evolution of the universe from very early times until the present epoch by including both the leading local correction $R^2$ and the leading non-local term $R\frac{1}{\square^2}R$ to the classical gravitational action. We find that the inflationary phase driven by $R^2$ term gracefully exits in a transitory regime characterized by ...
Alessandro Codello +2 more
openaire +6 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Inter university cooperation and social education. multicultural frame and joint curricula [PDF]
, 2014 1. No doubt about being upper levels in education a prioritarian way for the universalization of knowledge, as the authors more than once argued (see their Presentation at the previous Conference on Education 2012) 2.
BENVENUTO, Guido, VEGGETTI, Maria Serena
core
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Healthy University – University of Central Lancashire [PDF]
, 2015 In 1995, the University of Central Lancashire became one of the first few universities to establish a Healthy University initiative – now one of the longest-running initiatives of its kind worldwide.
Doherty, Sharon Helen, Dooris, Mark T
core
Leptogenesis in the Universe [PDF]
Advances in High Energy Physics, 2012 Leptogenesis is a class of scenarios in which the cosmic baryon asymmetry originates from an initial lepton asymmetry generated in the decays of heavy sterile neutrinos in the early Universe. We explain why leptogenesis is an appealing mechanism for baryogenesis.
Fong, Chee Sheng +2 more
openaire +6 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source