Results 121 to 130 of about 1,432,495 (305)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Preliminary design and construction planning of a new Santa Clara University student fitness and recreational facility [PDF]
, 2015 The Pat Malley Fitness and Recreation Center was built in 1999. At approximately 45,000 SF, the building cost was 8.8 million dollars. Malley includes three full length basketball courts, locker rooms, 10,000 ft2 workout and cardio space, a multi-purpose
Matoi, Justin +2 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
IET Power ElectronicsThe modular multilevel DC–DC transformer (MMDCT) provides a reliable solution to overcome the challenges of conventional dual‐active‐bridge converters in terms of power semiconductors ratings and dv/dt stress on transformer coupling windings.
Peizhou Xia +4 more
doaj +1 more source
Distribution and comparison of bacterial communities in HVAC systems of two university buildings: Implications for indoor air quality and public health. [PDF]
Environ Monit Assess, 2021 Sibanda T +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
A probabilistic model to evaluate the effectiveness of main solutions to COVID-19 spreading in university buildings according to proximity and time-based consolidated criteria. [PDF]
Build Simul, 2021 D'Orazio M, Bernardini G, Quagliarini E.
europepmc +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Nebelivka: From Magnetic Prospection to New Features of Mega-Sites [PDF]
, 2016 The international project at Nebelivka included three field seasons, funded by grants obtained by Prof. John Chapman (Durham University, UK).1 The Institute of Archaeology of NAS Ukraine, for its part, has provided researchers, obtained the necessary ...
Burdo, Nataliia, Videiko, Mykhailo
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source