Results 141 to 150 of about 16,275,120 (302)

GESTORES UNIVERSITÁRIOS: PAPEL E COMPETÊNCIAS NECESSÁRIAS PARA O DESEMPENHO DE SUAS ATIVIDADES NAS UNIVERSIDADES FEDERAIS

open access: yesRevista Gestão Universitária na América Latina, 2012
The university is an institution that has knowledge as its raw material and that exists to leverage society and to contribute to its development, aiming at the training of qualified professionals.
Humberto Tonani Tosta   +3 more
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

O BALANCED SCORECARD COMO FERRAMENTA DE GESTÃO ESTRATÉGICA EM UMA UNIVERSIDADE FEDERAL

open access: yesRevista Gestão Universitária na América Latina, 2012
The study’s aim is to structure a Balanced Scorecard for the Department of Accounting Sciences of Federal University of Santa Catarina, whose purpose is to align a business area (CCN) with the strategies defined by the corporation (UFSC).
Fernando Richartz   +3 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

CONHECIMENTO, UNIVERSIDADE E INOVAÇÃO: COMO SE RELACIONAM NA GERAÇÃO DE INOVAÇÃO BASEADA EM CONHECIMENTO

open access: yesRevista Gestão Universitária na América Latina, 2016
Universities as generators and diffuse rs of knowledge are innovation agents when they interact with the environment. The role of the university in support of innovation also depends on the regional context, what means that not all ...
Kelly Cristina Benetti Tonani Tosta   +2 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Desarrollo humano y sustentable como aspiración del desarrollo local: caso del programa interdisciplinario para el desarrollo integral de micro y pequeñas empresas en las regiones chorotega y pacífico central de Costa Rica

open access: yesSuma de Negocios, 2010
Local and sustainable development keeps on being a challenge for supporting agents and specialized organizations along the local intervention process. The reality shows that it is necessary to redefine the strategy emphazising on the participation and ...
Juan Carlos Picón Cruz   +1 more
doaj  

University-local industry linkages : the case of Tohoku University in the Sendai area of Japan [PDF]

open access: yes
This paper focuses on Tohoku University in Sendai in the nonmetropolitan area of Japan. Both a long historical and comparative perspective and a spacial perspective are essential to discuss the relevance of university-local industry linkages to local ...
Abe, Shiro, Harayama, Yuko, Jiang, Juan
core  

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