Results 101 to 110 of about 84,423,094 (271)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Self-esteem in girls: does physical education make a difference [PDF]

, 2002
vi, 54 leaves ; 29 cm. --The purpose of this study was to determine whether participation in a girls' physical education class can contribute to the development of self-esteem.
Howe, Lori, University of Lethbridge. Faculty of Education   +1 more
core  

Satisfaction of Online University Education during the COVID-19 Pandemic. [PDF]

Healthcare (Basel), 2023
Ortega-Donaire L, Bailén-Expósito J, Álvarez-García C, López-Medina IM, Álvarez-Nieto C, Sanz-Martos S.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Athlete's perceptions of sport and education : a comparision of high school 4A basketball players and midget AAA hockey players in Alberta [PDF]

, 2003
x, 85 leaves ; 29 cm.This study focused on student athletes' perceptions of sport and education. The following research question was used to establish a framework for this thesis: Is there a significant difference in athletes' perceptions of sport and ...
Morgan, Robert, University of Lethbridge. Faculty of Education   +1 more
core  

Retracted: The Reform of University Education Teaching Based on Cloud Computing and Big Data Background. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Europe and Africa: One continent in the university education The ERASMUS+ Programme. [PDF]

J Public Health Afr, 2023
Nzekwa N, Jimale MA, Orazi A, Colizzi V, Ndembi N.   +4 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Enhancing school-university partnerships. [PDF]

, 2001
Preservice teachers are offered school-based experiences as a component of their undergraduate teacher education programmes. While there have been major shifts toward establishing new types of partnerships between schools and teacher education providers ...
McGee, Judith
core