Results 121 to 130 of about 188,369,412 (295)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Ralph W. Gerald Convocation , University of California, Irvine
, 1974 Digitized 2015 by DUE Media Services at UC ...
University of California, Irvine
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Tobacco Use in California 1990: A Preliminary Report Documenting the Decline of Tobacco Use [PDF]
, 1990 SummaryThis report presents data on a partial sample of a survey of cigarette smoking behaviors and attitudes among Californians conducted during the summer of 1990. The prevalence of current smoking among adults in California is 21.2% with males (23.8%)
University of California, San Diego +1 more
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Elisa Morgera & Jona Razzaque, eds., Biodiversity and Nature Protection Law (Elgar Encyclopedia of Environmental Law Volume III) [PDF]
Law, Environment and Development Journal, 2017 Reviewed by David Takacs, University of California Hastings College of the Law & IELRC
doaj
The evolving role of alemtuzumab (Campath-1H) in renal transplantation
Drug Design, Development and Therapy, 2008 Phuong-Thu T Pham1, Gerald S Lipshutz2, Phuong-Truc T Pham3, Joseph Kawahji1, Jennifer S Singer4, Phuong-Chi T Pham51Division of Nephrology, Department of Medicine, Kidney and Pancreas Transplant Program, University of California at Los Angeles, David ...
Phuong-Thu T Pham +5 more
doaj
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Promoting anti-corruption, transparency and accountability to achieve universal health coverage
Global Health Action, 2020 Theadora Koller +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source