Results 111 to 120 of about 77,275,895 (245)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Do Rankings Reflect Research Quality? [PDF]
Publication and citation rankings have become major indicators of the scientific worth of universities and countries, and determine to a large extent the career of individual scholars.
Katja Rost, Bruno S. Frey
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RANKINGS ACADÊMICOS E UNIVERSIDADES DE CLASSE MUNDIAL: RELAÇÕES, DESDOBRAMENTOS E TENDÊNCIAS
Educação & SociedadeRESUMO: Neste artigo analisaram-se as relações entre os rankings acadêmicos e o modelo de Universidade de Classe Mundial, bem como a capacidade indutora desses instrumentos em termos de políticas, planejamento e gestão.
Lara Carlette Thiengo +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
RESEARCH IN ECONOMICS IN SPAIN: RANKINGS OF INSTITUTIONS AND AUTHORS [PDF]
In this paper we analyse the research in Economics in Spain during the 1990s considering the contributions of both Spanish and foreign economist who have worked in Spain during that period.
Juan J. Dolado +2 more
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University Rankings and Social Science : University Rankings and Social Science [PDF]
, 2014 University rankings widely affect the behaviours of prospective students and their families, university executive leaders, academic faculty, governments and investors in higher education.
Simon Marginson +2 more
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The problems of formation of world-class universities and the ranking positioning
Сеченовский вестник, 2014 The article introduces the concept of forming a «world-class university», discusses the possible strategies and the way to becoming the leading universities in the world. Shows the evolution of the international rankings, evaluation indicators.
V. N. Nikolenko +3 more
doaj
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source