Thrombotic mitral valve obstruction during venoarterial extracorporeal membrane oxygenation with left ventricular venting following complex valve surgery. [PDF]
J Cardiothorac SurgHao J, Lei L, Sun T, Xiao Y.
europepmc +1 more source
Advanced Science, EarlyView.A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu +17 more
wiley +1 more source
Mitochondrial Impairment in Unloaded Postural Muscle: Mechanisms Driving Loss of Muscle Function and Mass. [PDF]
Antioxidants (Basel)Sharlo KA, Mirzoev TM, Shenkman BS.
europepmc +1 more source
ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy
Advanced Science, EarlyView.A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou +9 more
wiley +1 more source
Architected Inverse Nacre Hydrogels With High Strength and Crack‐Insensitive Toughness
Advanced Science, EarlyView.Hydrogels hold promise for biomedical and engineering applications, yet their practical use is fundamentally limited by the strength‐toughness trade‐off and poor fatigue resistance. In this study, a bioinspired inverse nacre architecture constructed via a scalable thermo‐calendering process is introduced, which overcomes these classic limitations ...
Haidi Wu +10 more
wiley +1 more source
Ochratoxin A in bulk consignments of wheat, durum wheat, and barley sampled before and after trans-Pacific shipment. [PDF]
Mycotoxin ResTittlemier SA, Sekiyama A, Yamada Y.
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Advanced Science, EarlyView.This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka +4 more
wiley +1 more source
Microgravity as a translational model for metabolic dysfunction: implications for obesity, insulin resistance, steatotic liver and pancreatic diseases. [PDF]
Front Endocrinol (Lausanne)Vadukoot Lazar M +2 more
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Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
Safety compliance monitoring for oil tank unloading based on multimodal feature fusion and knowledge reasoning. [PDF]
Sci RepLiu T, Sun C, Wang B, Yao L.
europepmc +1 more source