Results 71 to 80 of about 2,845,268 (289)

Protein evolution in the presence of an unnatural amino acid [PDF]

, 2014
textThe field of protein engineering has been greatly augmented by the expansion of the genetic code using unnatural amino acids as well as the development of cell-free synthesis systems with high protein yield.
Singh, Amrita, active 2012
core   +1 more source

The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

Nature Communications, 2018
The capsaicin receptor TRPV1 has been structurally characterized, but the capsaicin activation dynamics remain elusive. Here authors use fluorescent unnatural amino acid incorporation, computational modeling and Φ-analysis to derive the capsaicin-bound ...
Fan Yang, Xian Xiao, Bo Hyun Lee, Simon Vu, Wei Yang, Vladimir Yarov-Yarovoy, Jie Zheng   +6 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Partial Synthesis of an Unnatural Amino Acid

, 2015
Unnatural fluorescent amino acids are important tools that allow biochemists to visualize proteins in living cells. The addition of an unnatural fluorescent amino acid makes these normally transparent proteins, glow-in-the-dark.
Salim, Arman D
core   +1 more source

ProRepeat: an integrated repository for studying amino acid tandem repeats in proteins [PDF]

, 2011
ProRepeat (http://prorepeat.bioinformatics.nl/) is an integrated curated repository and analysis platform for in-depth research on the biological characteristics of amino acid tandem repeats.
Harm Nijveen, Lin, K., Jack A. M. Leunissen, K. Lin, Audrey David, Luo, H., Ke Lin, A. David, David, A., H. Nijveen, H. Luo, Leunissen, J.A.M., Nijveen, H., Hong Luo, J. A. M. Leunissen   +14 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Manganese‐Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides

Advanced Science
Dehydroalanine (Dha), a readily introducible non‐canonical amino acid, is widely used for protein post‐translational modification (PTM) and site‐specific labeling of peptides and proteins.
Xinwei Hu, Chengwei Zheng, Xiaotong Song, Balati Hasimujiang, Mu Chen, Zhixiong Ruan   +5 more
doaj   +1 more source

Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels

eLife, 2017
EAG-like (ELK) voltage-gated potassium channels are abundantly expressed in the brain. These channels exhibit a behavior called voltage-dependent potentiation (VDP), which appears to be a specialization to dampen the hyperexitability of neurons.
Gucan Dai, William N Zagotta
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Comparative functional genomics of amino acid metabolism of lactic acid bacteria [PDF]

, 2009
The amino acid metabolism of lactic acid bacteria used as starters in industrial fermentations has profound effects on the quality of the fermented foods.
Pastink, M.I.
core