Advanced Science, EarlyView.Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang +6 more
wiley +1 more source
Knowledge-distilled diffusion models for improving cone-beam CT image quality with meta-learning under imbalanced data. [PDF]
Med PhysHwang J, Park S, Cho S, Kim JS.
europepmc +1 more source
Advanced Science, EarlyView.Multiferroic order parameters – polarization, magnetization, and ferroelastic strain – are positioned as dynamic design variables for batteries. Their mechanistic roles, practical tuning through fabrication and external fields, and ferroic‐resolved characterization routes are unified into a closed‐loop framework, revealing how coupled ferroic responses
Jiaqi Su +13 more
wiley +1 more source
Style-Semantic Disentangled Optical-to-Infrared Translation for Infrared Target Recognition. [PDF]
J ImagingLiu L, Niu J, Mu L.
europepmc +1 more source
Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source
Quality-Gated CycleGAN with Frequency-Split Composition for Structure-Constrained Contrast-Like Enhancement of Non-DICOM Chest CT: External Feasibility and Implications for Pulmonary Embolism AI. [PDF]
Bioengineering (Basel)Gill SH, Choi HY, Kim Y.
europepmc +1 more source
Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction
Advanced Science, EarlyView.Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen +5 more
wiley +1 more source
Translation of frozen sections into FFPE images for skin cancer resection margins using generative AI. [PDF]
NPJ Digit MedLee SH +8 more
europepmc +1 more source
Advanced Science, EarlyView.Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu +18 more
wiley +1 more source
CycleGAN-based image-to-image translation for synthetic contrast enhancement in non-contrast cardiac CT: a ViT-CNN hybrid deep learning approach. [PDF]
BMC Med Inform Decis MakPark D +4 more
europepmc +1 more source