Results 81 to 90 of about 97,810,316 (272)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Photogenic Guided Image-to-Image Translation With Single Encoder

IEEE Open Journal of the Computer Society
Image-to-image translation involves combining content and style from different images to generate new images. This technology is particularly valuable for exploring artistic aspects, such as how artists from different eras would depict scenes.
Rina Oh, T. Gonsalves
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

MS-GAN: Learn to Memorize Scene for Unpaired SAR-to-Optical Image Translation

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Synthetic aperture radar (SAR) and optical sensing are two important means of Earth observation. SAR-to-optical image translation (S2OIT) can integrate the advantages of both and assist SAR image interpretation under all-day and all-weather conditions ...
Zhe Guo, Zhibo Zhang, Qinglin Cai, Jiayi Liu, Yangyu Fan, Shaohui Mei   +5 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Background-focused contrastive learning for unpaired image-to-image translation

Journal of Electronic Imaging
Contrastive learning for unpaired image-to-image translation (CUT) aims to learn a mapping from source to target domain with an unpaired dataset, which combines contrastive loss to maximize the mutual information between real and generated images. However, the existing CUT-based methods exhibit unsatisfactory visual quality due to the wrong locating of
Mingwen Shao, Minggui Han, Lingzhuang Meng, Fukang Liu   +3 more
openaire   +2 more sources

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Enhancing Landscape Design Consistency Through CycleGAN-Based Style Translation and Preference Matching

IEEE Access
This paper presents a multimodal style consistency framework for landscape architecture. The method uses a two-stage analysis pipeline: (A) CycleGAN-driven unpaired style transfer from high-resolution site sketches; and (B) frozen-CLIP image–text ...
Yafei Zhou, Yaoyao Du
doaj   +1 more source

Unpaired Image-to-Image Translation for Segmentation and Signal Unmixing

Abstract This work introduces Ui2i, a novel model for unpaired image-to-image translation, trained on content-wise unpaired datasets to enable style transfer across domains while preserving content. Building on CycleGAN, Ui2i incorporates key modifications to better disentangle content and style features, and preserve content integrity.
Nikola Andrejic, Milica Spasic, Igor Mihajlovic, Petra Milosavljevic, Djordje Pavlovic, Filip Milisavljevic, Uros Milivojevic, Danilo Delibasic, Ivana Mikic, Sinisa Todorovic   +9 more
openaire   +3 more sources