Results 11 to 20 of about 551,118 (196)

Neutrophil extracellular traps mediate the crosstalk between plaque microenvironment and unstable carotid plaque formation [PDF]

Experimental and Molecular Medicine
The development of unstable carotid atherosclerotic plaques is associated with the induction of neutrophil extracellular traps (NETs) via the activation of diverse inflammatory mediators in the circulating bloodstream.
Yu Cao, Minghui Chen, Xinyu Jiao, Shuijie Li, Dong Wang, Yongxuan Zhan, Jiaju Li, Zhongfei Hao, Qingbin Li, Yang Liu, Yan Feng, Ruiyan Li, Hongjun Wang, Mingli Liu, Qiang Fu, Yongli Li   +15 more
doaj   +4 more sources

Residual cholesterol levels are associated with carotid plaque stability in patients with carotid stenosis [PDF]

Scientific Reports
Residual cholesterol (RC) is associated with an increased risk of atherosclerosis. High levels of RC have been shown to be associated with unstable plaque in healthy populations. However, the association between RC and unstable carotid plaque in specific
Wenzhuang Li, Kaiming Gao, Haihong Zhang, Pengcheng Wang, Hongguang Wang, Xiaoguang Tong   +5 more
doaj   +3 more sources

Multi‐omics integration and machine learning identify an ACKR1+ endothelial cell‐based lactate‐immune signature associated with carotid plaque vulnerability and progression [PDF]

Clin Transl Med
ACKR1+ endothelial cells mark intraplaque neovessels with hyperactive glycolysis and lactate metabolism. Lactate, HIF‐1α and CXCL12 link this state to CXCR4+ CD8+ T‐cell recruitment in situ. SLC16A3 and SLC16A4 serve as quantitative readouts of this lactate–immune state.
Zhang J, Zhao Q, Wu Y, Shu K, Chen J, Li K, Feng Y, Zhang X, Liu W, Lai Z, Liu B.   +10 more
europepmc   +2 more sources

FOXC1: A Key Transcription Factor of VSMC-Derived Foam Cell Formation in Atherosclerotic Plaque Instability. [PDF]

Kaohsiung J Med Sci
ABSTRACT The instability of atherosclerotic plaques, particularly intraplaque hemorrhage (IPH), drives life‐threatening cardiovascular events, a process in which vascular smooth muscle cell (VSMC)‐derived foam cells play a significant role. We aim to identify key biomarkers associated with VSMC‐derived foam cells and IPH by analyzing data from human ...
Qian LL, Li XL, Wang LH, Yang W, Jiang Y.   +4 more
europepmc   +2 more sources

Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque. [PDF]

BMC Cardiovasc Disord, 2016
2016 The Author(s). Background: Novel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors.
Auguet T, Aragonès G, Guiu-Jurado E, Berlanga A, Curriu M, Martinez S, Alibalic A, Aguilar C, Camara ML, Hernández E, Ruyra X, Martín-Paredero V, Richart C.   +12 more
europepmc   +2 more sources

Carotid plaque stress analysis by fluid structure interaction based on in-vivo MRI: Implications to plaque vulnerability assessment [PDF]

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 2010.Stroke is one of the leading causes of death in the world, resulting mostly from the sudden rupture of atherosclerotic plaques.
Gao, Hao
core   +8 more sources

A Case of Carotid Artery Stenting after Aspiration of Thrombus and Unstable Plaque

Journal of Neuroendovascular Therapy, 2020
There is no established method for carotid artery stenting (CAS) for internal carotid artery stenosis with vulnerable plaque and thrombosis. We report a case in which CAS was performed by aspiration using the Penumbra system for thrombosis that increased in the subacute phase in symptomatic cervical internal carotid artery stenosis.A 59-year-old man ...
Sadao Suga, Masateru Katayama
exaly   +4 more sources

Integrating untargeted metabolomics and deep learning approaches to identify specific metabolic signatures and new mechanisms in unstable plaques [PDF]

Frontiers in Cardiovascular Medicine
BackgroundUnstable carotid artery plaques are an important risk factor for ischemic stroke, and their clinical prognosis is poor. The present study to systematically investigate the metabolic changes of carotid plaques and use machine learning methods to
Jia-Qi Ma, Lu Wang, Lu Wang, Xiao-Peng Qu, Yue Zhang, Li-Jia Song, Guo-Dong Gao, Chao Wang, Long-Long Zheng, Qi-Xing Fang, Yan Qu, Liang-Liang Shen, Bei Liu   +12 more
doaj   +2 more sources

Role of abnormal phosphatidylcholine metabolism in endoplasmic reticulum stress-induced carotid artery plaque destabilization [PDF]

Atherosclerosis Plus
Background and aims: The imbalance of carotid plaque stability is a key cause of acute cardiovascular and cerebrovascular events. Lipid metabolism disorder and endoplasmic reticulum stress (ERS) are both involved in the progression of atherosclerotic ...
Qifei Hu, Haoran Zhang, Xianwei Wang, Jiaming Huang, Xiaohui Jiang, Mei Li, Dong Chen   +6 more
doaj   +2 more sources

Carotid plaque vulnerability assessment by microscopic morphology analysis, ultrasound and 3D model reconstruction [PDF]

, 2012
This thesis was submitted for the degree of Docter of Philosophy and awarded by Brunel University.Research suggests that plaque morphology plays a crucial role in determining plaque vulnerability.
Choudhury, Ahsan
core   +7 more sources