Results 51 to 60 of about 551,118 (196)
Assessment of vulnerable and unstable carotid atherosclerotic plaques on endarterectomy specimens
Experimental and Therapeutic Medicine, 2016 The types of lesion instability responsible for the majority of acute coronary events frequently include plaque disruption and plaque erosion with superimposed thrombosis. The term 'vulnerable plaque is used to describe atherosclerotic (ATS) plaques that are particularly prone to rupture and susceptible to thrombus formation, such as the thin-cap ...Doina, Butcovan, Veronica, Mocanu, Dana, Baran, Diana, Ciurescu, Grigore, Tinica +4 moreopenaire +3 more sourcesSerial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice
Advanced Science, EarlyView.A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill +12 morewiley +1 more sourceReconstruction and quantification of the carotid artery bifurcation from 3D ultrasound images [PDF]
, 2004 Three-dimensional (3-D) ultrasound is a relatively new technique, which is well suited to imaging superficial blood vessels, and potentially provides a useful, noninvasive method for generating anatomically realistic 3-D models of the peripheral ...Thom, S A M, Hughes, AD, Hughes, A D, Barratt, D C, Humphries, K N, Thom, SAM, Ariff, BB, Ariff, B B, Barratt, DC, Humphries, KN +9 morecore +1 more sourceTHSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A
Advanced Science, EarlyView.THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian +15 morewiley +1 more sourceRANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies. [PDF]
, 2011 The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be Hilma Holm, Poschen Ulrike, Panos Deloukas, Assimes, Themistocles L., Karakas, Mahir, Mahir Karakas, Erdmann, Jeanette, Moll, F.L., Robert Roberts, Illig, T., Samani, Nilesh J, Sekar Kathiresan, Muredach P Reilly, Koenig Wolfgang, Dominique P. V. de Kleijn, Herder, C., Thorand, Barbara, Illig Thomas, Preuss Michael, Pasterkamp, Gerard, Moll Frans L., null null, Ruth McPherson, König, Inke R, Poschen, Ulrike, Samani, Nilesh J., Karakas, M., Thorgeirsson, Gudmundur, de Kleijn Dominique P. V., Preuss, M, Frans L Moll, Alexandre F R Stewart, Meisinger Christa, Koenig, W., Holm, Hilma, de Kleijn, Dominique P. V., CARDIoGRAM Consortium, König, Inke R., Ulrike Poschen, Moll, Frans L, Roberts, Robert, Peeters, Wouter, Koenig, Wolfgang, Karakas Mahir, Müller-Nurasyid, Martina, Jeanette Erdmann, Wouter Peeters, Thorand Barbara, Meisinger, Christa, Herder Christian, Klopp, Norman, Roden, M., Herder, Christian, Moll, Frans L., Roden, Michael, Stewart, Alexandre FR, Gerard Pasterkamp, Heribert Schunkert, Martina Müller-Nurasyid, Müller-Nurasyid, M., Pasterkamp Gerard, Jens Baumert, Roden Michael, Klopp, N., McPherson, Ruth, Reilly, Muredach P, Inke R König, Deloukas, Panos, Schunkert, Heribert, Dominique P V de Kleijn, Kathiresan, Sekar, Wolfgang Koenig, Barbara Thorand, CARDIoGRAM Consortium (Illig, T. ; Wichmann, H.-E. ; Döring, A. ; Peters, A. ; Meitinger, T. ; Klopp, N. ; Meisinger, C.), Müller-Nurasyid Martina, Michael Preuss, Poschen, U., Preuss, Michael, Peeters, W., Illig, Thomas, Baumert, Jens, Reilly, Muredach P., Frans L. Moll, Christian Herder, Thomas Illig, Christa Meisinger, Stewart, Alexandre F. R., Klopp Norman, Meisinger, C., Assimes, Themistocles L, Peeters Wouter, de Kleijn, Dominique PV, Baumert Jens, de Kleijn, D.P., Stewart, Alexandre F R, de Kleijn, Dominique P V, Michael Roden, Themistocles L Assimes, Nilesh J Samani, Norman Klopp, Baumert, J.J., Thorand, B., Pasterkamp, G., Preuss, M., Schunkert, H., Kathiresan, S., Roberts, R., Erdmann, J., König, I.R., Deloukas, P., Assimes, T.L., Samani, N.J., Stewart, A.F., Baumert, J., Holm, H., McPherson, R., Reilly, M.P., Rice, K. (Kenneth), Meisinger, C. (Christa), Duijn, C.M. (Cornelia) van, Sinning, Christoph, Stewart, A.F.R. (Alexandre), Schillert, A. (Arne), Siscovick, D.S. (David), Go, Alan, Quertermous, T. (Thomas), Morrison, A.C. (Alanna), Linsel-Nitschke, P. (Patrick), Fortmann, S.P. (Stephen), Hengstenberg, Christian, Karakas M., Laaksonen, R. (Reijo), Whitteman, J. (Jaqueline), Grammer, T.B. (Tanja), Illig T., Nicaud, V., McPherson R., Peters, A. (Annette), Scharnagl, H. (Hubert), Waksman, R. (Ron), Ramachandran, V.S. (Vasan), Braund, P.S. (Peter), Moll F.L., Wright, B.J. (Benjamin), Chen, L. (Li), Blankenberg, Stefan, Samani N.J., Bis, J.C. (Joshua), Stark, K. (Klaus), Willenborg, C. (Christina), Blankenberg, S. (Stefan), Thorleifsson, G. (Gudmar), Bruse, P. (Petra), Laaksonen, Reijo, Stojakovic, T. (Tatjana), Boerwinkle, Eric, Zeller, Tanja, Dandona, S. (Sonny), Perret, C. (Claire), Meinitzer, A. (Andreas), Nelson, C.P. (Christopher P.), Barbalic, M. (maja), Wichmann, H.E. (Heinz Erich), Poschen U., Rotter, J.I. (Jerome), Illig, T. (Thomas), Tang, Hua, Folsom, A.R. (Aaron), Harris, T.B. (Tamara), Pichard, A.D., Waterworth, D. (Dawn), Wild, P.S. (Philipp), Andersen, K.K. (Karl), Burnett, M.S., Knouff, C.W. (Christopher), Li, Mingyao, Cupples, L.A. (Adrienne), Chen, I.Y.-D. (Ida Yii-Der), Voight, Benjamin F., Munzel, T. (Thomas), Preuss M., Heckbert, S.R. (Susan), Risch, N., Demissie-Banjaw, S. (Serkalem), Erdmann, J. (Jeanette), König, I.R. (Inke), Uitterlinden, Andre; id_orcid, Stewart, Alexandre F.R., Reilly M.P., Hlatky, Mark, Sidney, Steven, Klopp N., Hlatky, M.A. (Mark), Ziegler, A. (Andreas), Smith, N.L. (Nicholas), Rupprecht, H.J., Guiducci, C. (Candace), Stewart A.F., Schwartz, S.M. (Stephen), Wild, Philipp, Lindsay, J.M. (Joseph), van Duijn, Cornelia, Knowles, Joshua, Bickel, H. (Horst), Gretarsdottir, S. (Solveig), Wells, G.A. (George), Zeller, T. (Tanja), Zwart, J-A. (John-Anker), Tomaschitz, A. (Andreas), Hall, Alistair, Halperin, E. (Eran), Schnabel, Renate, Peeters W., Fortmann, Stephen, Winkler, K. (Karl), Cambien, F. (François), Hoffmann, M.M. (Michael), Altshuler, D. (David), Epstein, S.E. (Stephen), Thorsteinsdottir, Unnur, Levy, D. (Daniel), Preuss, M. (Michael), Roberts R., Koenig, W. (Wolfgang), Iribarren, Carlos, M乴ler-Nurasyid M., Koenig W., Hakonarson, H. (Hakon), Boerwinkle, E.A. (Eric), Kent, K.M. (Kenneth), Thompson, J.R. (John), Elosua, R. (Roberto), Lackner, K.J. (Karl), Wagner, A.K. (Arnika), Risch, Neil, Nahrstedt, J. (Janja), Renner, W. (Wilfried), Gudnason, V. (Vilmundur), Hengstenberg, C. (Christian), Walker, M.C. (Max), Cupples, L. Adrienne, Chen, Li, Reilly, M.P. (Muredach), Myers, Richard, McPherson, R. (Ruth), Qu, L. (Liming), Thompson, John R., Kong, A. (Augustine), Rader, D.J. (Daniel), Peltonen, L. (Leena Johanna), Schnabel, R.B. (Renate), Myers, R.H. (Richard), Doering, A. (Angela), Ball, S.G. (Stephen), Uitterlinden, A.G. (André), Wells, George A., Dobnig, H. (Harald), Absher, Devin, Dehghan, A. (Abbas), Hofman, A. (Albert), O'Donnell, C.J. (Christopher), Devaney, J. (Joseph), Quertermous, Thomas, Voight, B.F. (Benjamin), Assimes T.L., Roden M., de Kleijn D.P., Medack, A. (Anja), Sidney, S. (Steven), Schunkert H., Kleber, M. (Martina), Holm H., Jarinova, O. (Olga), Erdmann J., Thorgeirsson, G. (Gudmundur), Dehghan, Abbas, Hall, A. (Anne), Moll, F.L. (Frans), Balmforth, A.J. (Anthony), Mooser, V. (Vincent), März, W. (Winfried), Gabriel, S.B. (Stacey), Glazer, N.L. (Nicole), Roberts, R. (Robert), Thorleifsson, Gudmar, Großhennig, A. (Anika), Ziegler, Andreas, Meisinger C., Tiret, L. (Laurence), Salomaa, V. (Veikko), Melander, O. (Olle), Thorsteinsdottir, U. (Unnur), Matthai, W. (William), Samani, N.J. (Nilesh), Aherrahrou, Z. (Zouhair), Holm, H. (Hilma), Schunkert, H. (Heribert), Psaty, B.M. (Bruce), Thorand B., Tang, H. (Hui), Taylor, K.D. (Kent), Kathiresan S., Lumley, T. (Thomas), Kathiresan, S. (Sekar), Schreiber, S. (Stefan), Knowles, J.W. (Joshua), Sinning, C. (Christoph), Smith, A.V. (Davey), Li, M. (Mingyao), Hofman, Albert, Fischer, M. (Marcus), Deloukas P., Musunuru, K. (Kiran), Böhm, B., Lieb, W. (Wolfgang), Schillert, Arne, Baumert J., Proust, C. (Carole), Musunuru, Kiran, Klopp, N. (Norman), Winkelmann, B., Iribarren, C. (Carlos), Meitinger, T. (Thomas), Halperin, Eran, Go, A.T.J.I. (Attie), Herder C., Pilz, D.T. (Daniela), Loley, C. (Christina), Deloukas, P. (Panagiotis), Satler, L.F., Marciante, K. (Kristin), Gulcher, J.R. (Jeffrey), Pasterkamp G., Burtt, N.P. (Noël), Wilensky, A. (Asaf), K?nig I.R., Lackner, Karl, Volcik, K.A. (Kelly) +337 morecore +2 more sourcesConicity index and sex differences in relation to carotid plaque instability in Chinese community residents
Journal of Stroke and Cerebrovascular DiseasesObjectives: The conicity index (CI), an anthropometric parameter of visceral obesity, has exhibited a strong correlation with the incidence of atherosclerosis and cardiovascular events.Bi Deng, MD, Zeyu Liu, MD, Qin Huang, MD, Xianjing Feng, MD, Di Liao, MD, Fang Yu, MD, Jie Feng, MD, Qing Huang, MD, Yunhai Liu, MD, Jian Xia, MD +9 moredoaj +1 more sourceApproach To Unstable Plaque In Carotid Disease
Advances in Bioscience and Clinical Medicine, 2017 Risk of cerebral infarction due to thrombo emboli originating from carotid artery disease estimated to be near 15%, and this risk is closely associated with the severity of luminal stenosis. But at the same time characteristics of the plaque should be taken into account for therapeutic planning when the patient is asymptomatic and the diameter of ...openaire +2 more sourcesA Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment
Advanced Science, EarlyView.The mechanobiological basis of atherosclerotic progression and its contribution to spatial and temporal heterogeneity remain incompletely understood. Spatially resolved AFM measurements revealed that plaque formation and distinct regions (cap fibrosis, intimal fibrosis, and lipid‐rich core) exhibit heterogeneous elastic modulus and viscoelastic ...Yidan Zhou, Zhuo Chang, Xianjun Wu, Sijie Wang, Yuzhi Zhang, Hao Zhang, Haoyu Xu, Ruining Peng, Zhe Wang, Huiyun Xu, Yu Liu, Guangkui Xu, Nu Zhang, Hui Yang +13 morewiley +1 more sourceExtracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps
Advanced Science, EarlyView.Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia +20 morewiley +1 more source
