Unsupervised Ensemble Learning for Active Drug-Induced Liver Injury Surveillance: Integrating Pharmacokinetic Burden With Enzyme Trajectories. [PDF]
Pharmacoepidemiol Drug SafNakkaratniyom T +3 more
europepmc +1 more source
Advanced Science, EarlyView.Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang +9 more
wiley +1 more source
Post-MI: unsupervised brain tissue segmentation via post-maximized mutual information. [PDF]
Front Med (Lausanne)Niu K +7 more
europepmc +1 more source
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
Semi-Supervised Deep Image Stitching for Moving Elongated Objects. [PDF]
Sensors (Basel)Lai X, Xie Z, Liu X.
europepmc +1 more source
Q‐LEAP: Millisecond Hyperdimensional Optimization for Full‐Spectrum Optical Metamaterials
Advanced Science, EarlyView.Q‐LEAP integrates physics‐informed residual machine learning with factorization‐machine‐encoded quantum annealing to design full‐spectrum optical metamaterials. It explores a 2108 design space and, in a single 2.56 ms annealing step, reaches 85.83% of the theoretical FoM limit, enabling selective 5‐8 µm emission with 3–5 and 8–14 µm suppression and ∼40×
Zikang Guo +3 more
wiley +1 more source
Classification of Acoustic Emission Signals from Failure Modes in Thermoplastic Composites Using Machine Learning. [PDF]
Materials (Basel)Minhaj TB +4 more
europepmc +1 more source
Non‐Covalent Reversibly Photoconvertible Fluorescent Tags for Wash‐Free Protein Labeling
Advanced Science, EarlyView.FAST proteins combined with one or two fluorogens undergo reversible fluorescence switching or photoconversion through photoisomerization. At low fluorogen concentration and high light intensity, they act as negative or positive photoswitchers and photoconvertible tags, which are promising for discriminating FAST variants.
Mrinal Mandal +12 more
wiley +1 more source
Steroid Withdrawal Syndrome and Adrenal Insufficiency Following Unsupervised Steroid Use: A Case Report. [PDF]
Clin Case RepGautam SK +7 more
europepmc +1 more source
AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells
Advanced Science, EarlyView.Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding +12 more
wiley +1 more source