Results 91 to 100 of about 162,571 (289)

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

open access: yesAdvanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan   +21 more
wiley   +1 more source

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions

open access: yesAngewandte Chemie, EarlyView.
This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan   +3 more
wiley   +2 more sources

Overexpression of miR-484 and miR-744 in Vero cells alters Dengue virus replication

open access: yesMemorias do Instituto Oswaldo Cruz
BACKGROUND Dengue is considered one of the world’s most important mosquito-borne diseases. MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that play an important role in the regulation of gene expression in eukaryotes.
Juan Camilo Castrillón-Betancur   +1 more
doaj   +1 more source

Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5′-Untranslated Region Sequences [PDF]

open access: hybrid, 1999
Jack T. Rogers   +6 more
openalex   +1 more source

Genetic characterization of the coxsackievirus B2 3′ untranslated region

open access: yesJournal of General Virology, 2001
The secondary structure of the 3′ untranslated region (3′UTR) of picornaviruses is thought to be important for the initiation of negative-strand RNA synthesis. In this study, genetic and biological analyses of the 3′ terminus of coxsackievirus B2 (CVB2), which differs from other enteroviruses due to the presence of five additional nucleotides prior to ...
Charlotta, Polacek, A Michael, Lindberg
openaire   +2 more sources

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

open access: yesAdvanced Science, EarlyView.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu   +9 more
wiley   +1 more source

Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis

open access: yesAdvanced Science, EarlyView.
Additive and partially dominant effects, namely at mid‐parent levels or values between mid‐parent and parental levels, respectively, are the predominant inheritance patterns of heterosis‐associated molecules. These two genetic effects contribute to heterosis of agronomic traits in both rice and maize, as well as biomass heterosis in Arabidopsis ...
Zhiwu Dan   +8 more
wiley   +1 more source

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